| The hypolipidemic effects of corn lecithin for injection (CLFI) on high-fat diet rats were investigated. Totally 60 male SD rats were randomly and equally divided into six groups: blank control group, high fat model group, positive control group (1.2 g/kg soybean lecithin), and high-, middle-and low-dose CLFI (2.4, 1.2, 0.6 g/kg) groups. The rats in the blank control group were fed with normal diet, while the remaining groups were fed with high-fat diet for two weeks. Then the positive control group and each CLFI dose group were administered by gavage with the corresponding drugs, and the blank control group and high fat model group were intragastrically administered the same volume of distilled water (10 mL/kg) once a day. After six weeks of feeding, serum lipid parameters, body weight, abdominal fat coefficient (AFC), superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in both serum and liver tissue of rats were determined, and morphological changes in the liver of rats were observed. The results showed that CLFI could inhibit body weight gain induced by high-fat diet in rats, and reduce serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), MDA,atherosclerosis index (AI), and lipid comprehensive index (LCI) levels in serum as well as AFC and hepatic MDA content. In addition, the levels of SOD and high-density lipoprotein cholesterol (HDL-C) could increase for varying degrees, and fatty degeneration of the liver was improved. CLFI had potent hypolipidemic and hepatoprotective effects in hyperlipidemic rats. This study provided a theoretical basis for the development and industrial application of CLFI. |
