|
| Evaluation of genotoxicity of Calophyllum inophyllum seed oil |
| |
| DOI：10.12166/j.zgyz.1003-7969/2020.12.013 |
| KeyWord:Calophyllum inophyllum seed oil bone marrow erythrocyte micronucleus test sperm malformation test Ames test genotoxicity |
| FundProject:海南省创新能力建设计划-省属科研院所技术开发专项（KYYS-2018-34） |
|
| Hits: 1631 |
| Download times: 656 |
| Abstract: |
| Through the bone marrow erythrocyte micronucleus test, sperm malformation test in mice and Ames test, the genotoxicity of crude Calophyllum inophyllum seed oil was studied. The results showed that compared with the negative control group, the medium (1/4 LD50) and high (1/2 LD50) dose groups of crude Calophyllum inophyllum seed oil showed extremely significant differences in the bone marrow erythrocyte micronucleus test and sperm malformation test, and showed dose-dependant relationship, indicating positive result. The Ames test was negative for all dose groups. The presence of xanthones, coumarins, terpenoids and alkaloids in the oil might be the reason for the positive result of the genotoxicity. The doses of negative results of bone marrow erythrocyte micronucleus test and sperm malformation test in mice were obviously higher than the daily recommended oil intake dose of 500-600 mg/kg for adults weighing 50 kg. So the crude Calophyllum inophyllum seed oil was not genotoxic to the tested mice under the recommended oil intake. |
| View full text View/Add Comment Download reader |
| Close |
