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| 基于白芨多糖的牡丹籽油纳米乳凝胶的制备与质量评价 |
| Preparation and quality evaluation of peony seed oil nanoemulsion gel based on Bletilla striata polysaccharide |
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| DOI：10.12166/j.zgyz.1003-7969/2020.12.016 |
| 中文关键词: 牡丹籽油 白芨多糖 纳米乳凝胶 质量评价 |
| 英文关键词:peony seed oil Bletilla striata polysaccharide nanoemulsion gel quality evaluation |
| 基金项目:西安医学院2018年配套基金项目（2018PT63）；陕西省教育厅科技计划项目（18JK0671）；陕西高校青年创新团队建设项目（陕教\[2019\]90号）；西安医学院2017年国家基金培育项目（2017GJFY10）；西安医学院2018年青年科研基金项目（2018QN12） |
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| 中文摘要: |
| 采用高速剪切-高压均质-超声波联用技术制备牡丹籽油纳米乳，以白芨多糖交联卡波姆940制得水凝胶，再将牡丹籽油纳米乳加入水凝胶中制得牡丹籽油纳米乳凝胶。对牡丹籽油纳米乳及牡丹籽油纳米乳凝胶质量进行了评价。结果表明： 牡丹籽油纳米乳处方组成为牡丹籽油0.9%、PEG-40氢化蓖麻油1.8%、PEG400 0.3%，所得牡丹籽油纳米乳外观呈半透明液体，显淡蓝色乳光，粒径为（88.44±1.74）nm，Zeta电位为（-18.6±2.8）mV，PDI为0.538±0.084，电导率为（8.27±0.11）μS/cm，黏度为（47.24±0.55）mPa·s，该纳米乳在室温下稳定性良好，高速离心后稳定性良好；牡丹籽油纳米乳凝胶外观呈棕黄色，均匀细腻易于涂布，pH为6.82±0.03，黏度为（53 829±146）mPa·s，牡丹籽油含量为（2.60±0.03）mg/g, 具有良好缓释效果。牡丹籽油纳米乳凝胶的制备工艺简单，可为牡丹籽油在药品和化妆品领域的研究开发提供参考。 |
| 英文摘要: |
| The combined techniques of high speed shear-high pressure homogenization-ultrasonic were adopted to prepare the peony seed oil nanoemulsion, the Bletilla striata polysaccharide was crosslinked with carporated 940 to prepare gel, and the peony seed oil nanoemulsion was added into gel to prepare peony seed oil nanoemulsion gel, then the qualities of the peony seed oil nanoemulsion and nanoemulsion gel were evaluated. The results showed that the optimal formula of the peony seed oil nanoemulsions was obtained as follows: peony seed oil 0.9%, PEG-40 hydrogenated castor oil 1.8%, and PEG400 03%. The appearance of peony seed oil nanoemulsion showed translucent liquid and nattier blue opalescence,with the diameter of （88.44±1.74）nm, the Zeta potential of （-18.6±2.8）mV, the PDI of 0538±0.084, the conductivity of （8.27±011）μS/cm, and the viscosity of （4724±0.55）mPa·s. The peony seed oil nanoemulsion was stable at room temperature and after high speed centrifugation. The appearance of peony seed oil nanoemulsion gel showed tan,uniform exquisite and easy to spread, with the pH of 6.82±0.03, the viscosity of （53 829±146）mPa·s, the peony seed oil content of （2.60±0.03）mg/g, and had a good slow-release effect. The preparation of peony seed oil nanoemulsion gel was simple, and the research could provide a reference for application of peony seed oil in medicine and cosmetics. |
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