| The hypolipidemic effects of different proportions of safflower seed oil and perilla seed oil was explored. 60 normal mice were randomly divided into blank group, safflower seed oil, perilla seed oil and proportions of safflower seed oil to perilla oil 1.18∶ 1, 2.59∶ 1, 5.42∶ 1 groups, 48 normal rats were randomly divided into blank group, proportions of safflower seed oil to perilla seed oil 0.47∶ 1, 2.59∶ 1, 401∶ 1, 5.42∶ 1, 8.25∶ 1 groups. Blank group was given saline, the remaining groups were given the corresponding proportion of oil, and the amount of gavage dose was 10 mL/kg. After 30 d of gavage, mouse blood and rats blood and liver were taken, and the total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) levels were measured by total biochemical analyzer. The results showed that compared with blank group, TG and TC level of mice in 259∶ 1 group and 5.42∶ 1 group significantly decreased, LDL-C level in 2.59∶ 1 group had a significantly decrease, and HDL-C level in 2.59∶ 1 group and 5.42∶ 1 group had a significant increase. Compared with blank group, serum TG and TC levels of rats significantly decreased in 047∶ 1 group and very significantly decreased in 2.59∶ 1 group, LDL-C level in the two groups also markedly reduced. For HDL-C level, there was a significant increase in 2.59∶ 1 group. Compared with blank group, TC level of rat in liver significantly decreased in the 0.47∶ 1 group and very significantly decreased in 2.59∶ 1 group, TG level very significantly decreased in 2.59∶ 1 group and significantly decreased in 4.01∶ 1 group, and LDL-C level significantly decreased in 0.47∶ 1 group and 2.59∶ 1 group. Safflower seed oil and perilla seed oil in different proportions had a hypolipidemic effects on normal animals, and the hypolipidemic effect of 2.59∶ 1 group was the most obvious. |
