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| Toxicological assessment of fresh pressed oil-tea camellia seed oil |
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| DOI：10.12166/j.zgyz.1003-7969/2020.03.015 |
| KeyWord:fresh pressed oil-tea camellia seed oil safety toxicology acute toxicity genetic toxicity sub-acute toxicity |
| FundProject:2018年度湖南省科技重大专项（2018NK1030） |
| Author Name | Affiliation | | CHEN Jinsong
TAN Chuanbo
YANG Yaoxue
LAI Qiongwei
ZHOU Gangping
ZHANG Fan
LU Fangguo
WU Suxi | 1.Hunan Great Sanxiang Camellia Oil Co.,Ltd., Hengyang 421141, Hunan, China
2.School of Medicine,Hunan University of Chinese Medicine, Changsha 410208,China
3.School of Chemistry and Bio-engineering,Changsha University of Science & Technology, Changsha 410114,China |
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| Abstract: |
| Acute toxicity test, genetic toxicity tests and sub-acute toxicity test of fresh pressed oil-tea camellia seed oil were performed to evaluate its safety. The results showed that acute toxicity test in rats demonstrated actual non-toxicity of fresh pressed oil-tea camellia seed due to its LD50 higher than 10 000 mg/kg. The results of genotoxicity tests (Ames test, mouse bone marrow cells micronucleus test and mammalian cell chromosome aberration test in vitro) were negative. No abnormal changes of animal health, biochemical indexes of blood and organ morphology were found in the 28 d feeding test of rats.The fresh pressed oil-tea camellia seed oil had no acute toxicity, genetic toxicity and sub-acute toxicity, so it had high edible safety. |
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