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| Effect of CCSKO on the body fat and serum lipid levels in obese mice induced by high-fat diet |
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| DOI：10.12166/j.zgyz.1003-7969/2020.04.015 |
| KeyWord:CCSKO reducing body fat reducing serum lipid level dose-effect relationship |
| FundProject:国家国际科技合作专项项目（2011DFA32770）；江西省科技支持计划重大项目（20143ACG70015）； 2015—2016年度南昌大学食品科学与技术国家重点实验室自由探索课题（SKLF-ZZB-201517）；国家自然科学基金青年科学基金项目（31701651） |
| Author Name | Affiliation | | LI Yanchen
LIN Hui
LI Yitong
ZENG Zheling
YU Ping
WEN Xuefang | 1.School of Resource, Environmental and ChemicalEngineering, Nanchang University, Nanchang 330031,China
2. Jiangxi Province Key Laboratory of Edibleand Medicinal Plant Resources, Nanchang University,
Nanchang 330031, China
3. State Key Laboratory ofFood Science and Technology, Nanchang University,Nanchang 330047, China
4. Institute of AppliedChemistry, Jiangxi Academy of Science, Nanchang
330096, China |
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| Abstract: |
| The high fat diet induced obese mice model was used to investigate the body fat and lipid levels reducing effect of Cinnamomum camphora seed kernel oil (CCSKO). The C57BL/6 mice were fed with standard feed as normal control group (NC group). Meanwhile, obese C57BL/6 mice were induced with the high fat diet. The high fat diet induced obese C57BL/6 mice were randomly divided into five groups: naturally restoring group (NR group), high fat diet (HF group), a mixture of lard and CCSKO oil (HF-25%CCSKO group(21.94%CCSKO, m(CCSKO)∶ m(lard)=1∶ 3), HF-50%CCSKO group (4383%CCSKO, m（CCSKO）∶ m（lard）=1∶ 1) and HF-100%CCSKO group (87.66%CCSKO, the lard was completely replaced by CCSKO). The animals were then fed with the above mentioned diets for ten weeks. The body weight, body length, abdominal fat, serum biochemistry parameters as well as liver histological examination were determined at the termination of experiment. The results showed that the body weight, abdominal fat weight, serum ALT and AST in HF-50%CCSKO group and HF-100%CCSKO group were significantly lower than the HF group. The TC, LDL-C, LDL-C/HDL-C ratio in HF-100%CCSKO group were significantly lower compared with the HF group. There was no significant difference between the HF-50%CCSKO group and the HF group in the TC, LDL-C, LDL-C/HDL-C ratio. The results of liver histological examination showed that the fat accumulation and steatosis in the liver were reduced in the HF-CCSKO 50% group and HF-100%CCSKO group. All together, these results suggested that CCSKO had the effect on reducing body fat and serum lipid levels with a dose dependent relationship. The benefits of body fat and serum lipid levels reducing effect could be observed when 50% or more lard in high fat diet was replaced with CCSKO. CCSKO was a capric and lauric MCTs, which was different from commercially available MCTs riched in caprylic acid and decanoic acid. The underlying mechanisms of reducing fat accumulation and lowering blood lipid levels in obese mice by these two types of MCTs might have similarities and differences. |
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