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| Effects of Moringa oleifera seed oils extracted by two extraction technologies on immunologic activity in mice |
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| DOI：10.12166/j.zgyz.1003-7969/2020.06.019 |
| KeyWord:press solvent extraction M. oleifera seed oil immunologic function mice |
| FundProject:国家自然科学基金项目(31560431) |
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| Abstract: |
| The effects of M. oleifera seed oils extracted by two extraction technologies (pressing and ultrasound-assisted solvent extraction)on immunologic activity of mice were studied.The prednison was intragastric administrated to the mice for two weeks to establish the immunodepressive model. Mice were randomly divided into ten groups according to the weight, including control group(5% sodium carboxymethyl cellulose,20 mL/kg), model group (prednison，10 mg/kg), dose groups of M.oleifera seed oils(1, 2 g/kg) of two extraction technologies, M.oleifera seed oils(1, 2 g/kg) plus prednison group. All the groups were administrated orally for two weeks.Then the body weight,clearance index, phagocytosis index, immune organ (thymus and spleen) index of the mice were determined to study the effect of two M.oleifera seed oils on immunologic activity of mice. The results showed that compared with control group，the high dose groups of the two M.oleifera seed oils could obviously enhance the thymus and spleen indexes, phagocytosis index and clearance index of the normal mice(P<0.05 or P<0.01). Compared with the model group, the high dose groups of the two M.oleifera seed oils could significantly improved the immunity organ index,phagocytosis index and clearance index of the immunocompromised mice (P<0.01),but had no significant effect on the body weight of the mice,which proved that M. oleifera seed oils extracted by the two extraction technologies had equivalent immune-enhancing effects and were dose-dependent. |
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