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| 两种提取工艺的辣木籽油对小鼠免疫活性的影响 |
| Effects of Moringa oleifera seed oils extracted by two extraction technologies on immunologic activity in mice |
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| DOI：10.12166/j.zgyz.1003-7969/2020.06.019 |
| 中文关键词: 压榨 溶剂萃取 辣木籽油 免疫功能 小鼠 |
| 英文关键词:press solvent extraction M. oleifera seed oil immunologic function mice |
| 基金项目:国家自然科学基金项目(31560431) |
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| 中文摘要: |
| 探讨两种提取工艺（压榨和超声辅助溶剂萃取）所得辣木籽油对小鼠免疫活性的影响。采用醋酸泼尼松灌胃处理小鼠建立免疫抑制动物模型，将小鼠按体重随机分为空白组(5%羧甲基纤维素钠，20 mL/kg)、模型组（醋酸泼尼松，10 mg/kg）、两种提取工艺辣木籽油（1、2 g/kg）剂量组、两种提取工艺辣木籽油（1、2 g/kg）+醋酸泼尼松剂量组。小鼠经连续灌胃给药2周，测定小鼠体重、廓清指数、吞噬指数、免疫器官（胸腺和脾脏）指数，研究两种提取工艺辣木籽油对小鼠免疫活性的影响。结果表明：与空白组相比，两种提取工艺辣木籽油高剂量组均能显著增加正常小鼠脾脏指数、胸腺指数、巨噬细胞吞噬指数和廓清指数(P<0.05或P<0.01）；与模型组相比，两种提取工艺辣木籽油高剂量组对免疫抑制小鼠免疫器官（胸腺和脾脏）指数、巨噬细胞吞噬指数和廓清指数均有显著增强作用(P<0.01），但对其体重无显著影响。证明两种提取工艺的辣木籽油具有等效的免疫增强作用且具有剂量依赖性。 |
| 英文摘要: |
| The effects of M. oleifera seed oils extracted by two extraction technologies (pressing and ultrasound-assisted solvent extraction)on immunologic activity of mice were studied.The prednison was intragastric administrated to the mice for two weeks to establish the immunodepressive model. Mice were randomly divided into ten groups according to the weight, including control group(5% sodium carboxymethyl cellulose,20 mL/kg), model group (prednison，10 mg/kg), dose groups of M.oleifera seed oils(1, 2 g/kg) of two extraction technologies, M.oleifera seed oils(1, 2 g/kg) plus prednison group. All the groups were administrated orally for two weeks.Then the body weight,clearance index, phagocytosis index, immune organ (thymus and spleen) index of the mice were determined to study the effect of two M.oleifera seed oils on immunologic activity of mice. The results showed that compared with control group，the high dose groups of the two M.oleifera seed oils could obviously enhance the thymus and spleen indexes, phagocytosis index and clearance index of the normal mice(P<0.05 or P<0.01). Compared with the model group, the high dose groups of the two M.oleifera seed oils could significantly improved the immunity organ index,phagocytosis index and clearance index of the immunocompromised mice (P<0.01),but had no significant effect on the body weight of the mice,which proved that M. oleifera seed oils extracted by the two extraction technologies had equivalent immune-enhancing effects and were dose-dependent. |
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