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| Antioxidation in vivo of total flavonoids from black sesame |
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| DOI：10.12166/j.zgyz.1003-7969/2020.07.010 |
| KeyWord:black sesame total flavonoids antioxidation aging model |
| FundProject:西安医学院药学省级重点学科建设项目（2016YXXK09，2016YXXK16）；西安市未央区科技计划项目（201930）；西安医学院国家自然科学基金培育项目（2017GJFY13）；国家自然科学基金（81903288）;西安市科技计划项目（2020KJRC0135） |
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| Abstract: |
| To evaluate the antioxidation in vivo of total flavonoids from black sesame, the aging model mice were induced by subcutaneous injection of D-galactose at neck back, and intragastrily administrated with total flavonoids from black sesame. Behavioral changes of mice were evaluated by rotary rod fatigue tester and weight-bearing swimming test. The indexes of thymus, spleen and brain were calculated. The activities of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) content in serum and brain tissue homogenate were detected. The pathological morphological changes in brain tissue were observed by HE staining. The results showed that compared with the model group the high dose of total flavonoids from black sesame could significantly prolong the weight-bearing swimming time, significantly increase brain index and the activities of T-SOD and GSH-Px (P<0.05), and decrease MDA content in serum (P<0.05). The high and medium dose of total flavonoids from black sesame could significantly increase the activity of T-SOD in brain tissue, and reduce MDA content (P<0.05). HE staining results showed that the high dose of total flavonoids from black sesame could relieve brain tissue damage.The total flavonoids from black sesame had anti-aging activity via antioxidant capacity. |
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