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| Progress in action mechanism of omega-3 polyunsaturated fatty acids in hyperlipidemia |
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| DOI：10.12166/j.zgyz.1003-7969/2020.07.021 |
| KeyWord:hyperlipidemia omega-3 polyunsaturated fatty acid lipid metabolism |
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| Abstract: |
| Hyperlipidemia is a metabolic disorder. Hyperlipidemia directly causes or causes diseases that seriously endangers human health, such as atherosclerosis, coronary heart disease, etc. Omega-3 polyunsaturated fatty acids can significantly reduce total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL), and very low density lipoprotein(VLDL) in rat and human serum, and increase the content of high density lipoprotein(HDL). Its action mechanism is mainly to increase exogenous cholesterol metabolism, reduce endogenous cholesterol synthesis, inhibit the expression of liver cholesterol transport-related genes and inhibit liver apolipoprotein production. It plays an important role in the prevention and treatment of hyperlipidemia and its related metabolic diseases. Based on the regulation of omega-3 polyunsaturated fatty acids on blood lipid level at home and abroad, the related action mechanisms of omega-3 polyunsaturated fatty acids in hyperlipidemia were systematically reviewed, in order to provide a reference for the further study of omega-3 polyunsaturated fatty acids on the mechanism of regulation of lipids and lipid metabolism, and for the subsequent research and development of related drugs. |
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