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| 薏苡仁油软胶囊的急性毒性和亚急性毒性研究 |
| Acute toxicity and subacute toxicity of coix seed oil soft capsule |
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| DOI：10.12166/j.zgyz.1003-7969/2020.08.013 |
| 中文关键词: 薏苡仁油软胶囊；急性毒性；30 d喂养试验 毒性 组织病理学 |
| 英文关键词:coix seed oil soft capsule acute toxicity 30-day feeding test toxicity histopathology |
| 基金项目:福州市科技计划项目（2018-G-81） |
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| 中文摘要: |
| 研究薏苡仁油软胶囊的毒性。按照《保健食品检验与评价技术规范（2003版）》中小鼠经口急性毒性试验和大鼠30 d喂养试验，研究薏苡仁油软胶囊的急性毒性和亚急性毒性。结果表明：薏苡仁油软胶囊的小鼠经口最大耐受量（MTD）大于17.4 g/（kg·d）；大鼠30 d喂养试验未观察到中毒表现，薏苡仁油软胶囊各剂量组大鼠的一般情况、食物利用率、体重、脏器质量、脏体比均无异常改变；血常规和生化指标均在正常范围内，大鼠的各脏器病理组织检查与对照组比较差异无显著性（P>0.05）。因此，薏苡仁油软胶囊属于无毒类，是一种安全的保健食品。 |
| 英文摘要: |
| The toxicity of coix seed oil soft capsule was investigated. According to the Technical Standards for Testing & Assessment of Health Food issued in 2003, the acute toxicity and subacute toxicity of coix seed oil soft capsule were observed by oral acute toxicity test for mice and 30-day feeding test for rats. The results showed that the oral maximum tolerance dosage (MTD) of mice was over 17.4 g/(kg·d) and no toxicity was observed in the 30-day feeding test for rats. There was no significant difference in general condition，body weight, food availability, organ weight and organ coefficient in the rats of various dose groups.The results of blood routine and biochemical indexes showed that all the indexes were within the normal range. In addition, there was no significant difference in pathological tissue examination of various organs between coix seed oil group and control group（P>0.05）. Therefore, coix seed oil soft capsule belonged to non-toxic category, and it was a safe health food. |
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