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| Acute toxicity and subacute toxicity of coix seed oil soft capsule |
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| DOI：10.12166/j.zgyz.1003-7969/2020.08.013 |
| KeyWord:coix seed oil soft capsule acute toxicity 30-day feeding test toxicity histopathology |
| FundProject:福州市科技计划项目（2018-G-81） |
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| Abstract: |
| The toxicity of coix seed oil soft capsule was investigated. According to the Technical Standards for Testing & Assessment of Health Food issued in 2003, the acute toxicity and subacute toxicity of coix seed oil soft capsule were observed by oral acute toxicity test for mice and 30-day feeding test for rats. The results showed that the oral maximum tolerance dosage (MTD) of mice was over 17.4 g/(kg·d) and no toxicity was observed in the 30-day feeding test for rats. There was no significant difference in general condition，body weight, food availability, organ weight and organ coefficient in the rats of various dose groups.The results of blood routine and biochemical indexes showed that all the indexes were within the normal range. In addition, there was no significant difference in pathological tissue examination of various organs between coix seed oil group and control group（P>0.05）. Therefore, coix seed oil soft capsule belonged to non-toxic category, and it was a safe health food. |
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