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| Preparation and characterization of freeze-driedEucommia ulmoides seed oil liposome |
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| DOI： |
| KeyWord:Eucommia ulmoides seed oil freeze-dried liposome freeze-drying protectant storage stability |
| FundProject:湖南省科技厅重点研发计划项目(2018NK2045) |
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| Abstract: |
| In order to improve the stability, solubility and bioavailability of Eucommia ulmoides seed oil, the freeze-dried Eucommia ulmoides seed oil liposome was prepared by ethanol injection-ultrasound method and freeze-drying. Using appearance, redispersibility and encapsulation efficiency after rehydration of the samples as indexes, the freeze-drying conditions were optimized. The characteristics of the liposome including microform, particle size, Zeta potential and storage stability were determined, and the differential scanning calorimetry (DSC), X-ray diffraction (XRD) were used to analyze the state of freeze-drying protectant. The results showed that the optimal freeze-drying conditions of preparing Eucommia ulmoides seed oil liposome were obtained as follows: pre-freezing temperature -50?℃, pre-freezing time 12 h, drying time 36 h, with mannitol as freeze-drying protectant, mass ratio of mannitol to soy lecithin 8∶?1. Under these conditions, the liposome was white spheroid, and the capsulation efficiency after rehydration, particle size, PDI and Zeta potential were (72.52±1.95)%, (389.67±4.81)nm, 0.255±0.013 and (-22.62±1.66)mV, respectively. The liposome obtained had good storage stability. |
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