| Rat models of hypercholesterolemia and hypertriglyceridemia were established, and seal oil was administered orally to study the intervention effect of seal oil on the blood lipids of the two model rats. In addition, the effect of seal oil on the blood lipids of normal rats was studied. The results showed that for hypercholesterolemia rats, seal oil could reduce the TG, TC and LDL-C levels and significantly increase the ratio of HDL-C to TC (p<0.01) in rats, and the HDL-C level significantly increased (p<005) in the high-dose group (0.67 g/kg) rats; for hypertriglyceridemia rats, seal oil could reduce the TG and TC levels and significantly increase the ratio of HDL-C to TC (p<0.01) in rats; for normally fed rats, seal oil had no significant effect on the body weight, food utilization rate, organ coefficient and serum biochemical indexes of the rats. In summary, oral administration of seal oil to hypercholesterolemia or hypertriglyceridemia rats could effectively reduce the TC and TG levels in the two model rats, while oral administration of seal oil to normal rats had no effect on the body weight, food intake, serum biochemical indexes and various organs of normal rats. |
