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| Protective effect of walnut protein polypeptide on LPS-induced acute liver injury in mice |
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| DOI： |
| KeyWord:walnut protein polypeptide lipopolysaccharide (LPS) acute liver injury inflammatory factor protective effect |
| FundProject:云南省重大科技专项（2018ZG003） |
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| Abstract: |
| The model of acute liver injury induced by lipopolysaccharide (LPS) in mice was established to study the protective effect of walnut protein polypeptide (WPP) on liver injury. Mice were randomly divided into five groups (blank control group, LPS model group, LPS+WPP low-dose group, LPS+WPP medium-dose group and LPS+WPP high-dose group). After continuous administration of WPP for five weeks, LPS was injected into tail vein to induce liver injury. The liver index, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in liver tissue, histopathological changes, serum IL-1β and IL-6 were detected. The results showed that compared with the LPS model group, the liver index of the mice in the WPP high-dose group was significantly reduced(P<0.05), the ALT and AST activities in the serum of mice in the WPP medium and high-dose groups decreased extremely significantly (P<001), the levels of IL-1β and IL-6 in the serum of mice in the WPP low, medium and high-dose groups decreased extremely significantly (P<001), the SOD activites in the liver tissues of mice in the WPP medium and high-dose groups increased significantly（P<0.05）, and the GSH-Px activities in the liver tissues of mice in the WPP low, medium and high-dose groups increased extremely significantly (P<0.01). Histopathological observation showed that the pathological injury of the liver tissue in the WPP low, medium and high-dose groups was significantly reduced. WPP had obvious protective effect on LPS-induced acute liver injury in mice . |
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