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Progress in inhibiting tumor of conjugated linoleic acid
  
DOI：
KeyWord:conjugated linoleic acid  endoplasmic reticulum stress  cancer cell  apoptosis  peroxisome proliferator-activated receptor γ  conjugated linoleic acid derivatives
FundProject:中央高校基本业务基金（XDJK2020RC001）； 2019年西南大学大学生创新创业训练项目（X201910635051）
Author NameAffiliation
FENG Haizhou College of Animal Science, Southwest University, Chongqing 400000, China） 
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Abstract:
      Conjugated linoleic acid (CLA) has a variety of biological activities such as affecting immune function and preventing obesity, diabetes and atherosclerosis. It also has the effect of inhibiting tumors, such as delaying skin cancer, promoting the apoptosis of human breast cancer and prostate cancer cells.The research progress of the mechanism of CLA on inhibiting tumor in recent years was reviewed, including the regulation of eicosanoid metabolism to affect cancer cell apoptosis (endoplasmic pathway), as a ligand activating peroxisome proliferator-activated receptor γ (PPARγ) to regulate cell differentiation and metabolism (nuclear pathway), and inducing cancer cells to produce endoplasmic reticulum stress pathways to regulate cell metabolism, the safety of CLA and the anti-tumor effect of special derivatives of CLA were also reviewed, in order to provide basic information for the comprehensive utilization of CLA as a cancer suppressing additive.
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