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| 共轭亚油酸抑制肿瘤的研究进展 |
| Progress in inhibiting tumor of conjugated linoleic acid |
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| DOI： |
| 中文关键词: 共轭亚油酸 内质网应激 癌细胞 细胞凋亡 过氧化物酶体增殖剂激活受体 共轭亚油酸衍生物 |
| 英文关键词:conjugated linoleic acid endoplasmic reticulum stress cancer cell apoptosis peroxisome proliferator-activated receptor γ conjugated linoleic acid derivatives |
| 基金项目:中央高校基本业务基金（XDJK2020RC001）； 2019年西南大学大学生创新创业训练项目（X201910635051） |
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| 中文摘要: |
| 共轭亚油酸（CLA）具有多种生物活性，如能影响免疫功能并具有预防肥胖、糖尿病和动脉粥样硬化的作用，同时还具有抑制肿瘤的作用，如具有延缓皮肤癌、促进人乳腺癌和前列腺癌细胞的凋亡等作用。对近年来CLA抑制肿瘤作用机制的研究进展进行综述，包括调节类二十烷酸的代谢影响癌细胞凋亡（内质途径），作为配体激活过氧化物酶体增殖剂激活受体γ（PPARγ）调节细胞的分化和代谢（核途径），以及诱导癌细胞产生内质网应激途径调节细胞代谢。同时对CLA的安全性和CLA特殊衍生物的抑制肿 |
| 英文摘要: |
| Conjugated linoleic acid (CLA) has a variety of biological activities such as affecting immune function and preventing obesity, diabetes and atherosclerosis. It also has the effect of inhibiting tumors, such as delaying skin cancer, promoting the apoptosis of human breast cancer and prostate cancer cells.The research progress of the mechanism of CLA on inhibiting tumor in recent years was reviewed, including the regulation of eicosanoid metabolism to affect cancer cell apoptosis (endoplasmic pathway), as a ligand activating peroxisome proliferator-activated receptor γ (PPARγ) to regulate cell differentiation and metabolism (nuclear pathway), and inducing cancer cells to produce endoplasmic reticulum stress pathways to regulate cell metabolism, the safety of CLA and the anti-tumor effect of special derivatives of CLA were also reviewed, in order to provide basic information for the comprehensive utilization of CLA as a cancer suppressing additive. |
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