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| Preparation and properties of peony seed oil microemulsion |
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| KeyWord:peony seed oil microemulsion pseudo-ternary phase diagram drip method |
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| Abstract: |
| The peony seed oil microemulsion was prepared by phase change observation method and pseudo-ternary phase diagram method. Different surfactants, hydrophilic-lipophilic balance (HLB) value and co-surfactant were studied to determine the composition of peony seed oil microemulsion. Then the preparation conditions of peony seed oil microemulsion were optimized through single factor experiment and orthogonal experiment. The results showed that the system composition of peony seed microemulsion was determined as peony seed oil/ Tween 80/ Span 80/ anhydrous ethanol/ water. The optimal preparation conditions were obtained as follows: temperature 25 ℃, Tween 80 and Span 80(mass ratio 6∶ 4)as the mixed surfactant,mixed surfactant HLB value 11,ratio of mixed surfactant to co-surfactant 1∶ 1; the order of addition was to first mix the mixed surfactant and peony seed oil, then adding water dropwise. Under the optimal conditions,the conformation of the microemulsion changed from W/O to bicontinuous (BC)first then to O/W with the adding of water;the appearance of the prepared peony seed oil microemulsion was a pale yellow transparent liquid,and the particle size was (4063±1.77)nm,the polydispersity coefficient was stable at 0218±0003, the conductivity was (681.75±1915)mS/cm. It was also found that the presence of low concentration of salt ions (≤1.0 mol/L) could promote the formation of peony seed oil microemulsion, but excessively high salt ions (≥1.5 mol/L) inhibited the formation of microemulsion. |
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