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| Toxicity on SD pregnant rats and teratogenicity in fetal rats fed by Xanthoceras sorbifolium Bunge. seed oil |
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| DOI： |
| KeyWord:Xanthoceras sorbifolium Bunge. seed oil maternal toxicity embryo toxicity teratogenicity |
| FundProject:赤峰市本级重点区域绿化项目（2130218）；内蒙古自治区科技重大专项（ZDZX2018056）；内蒙古自治区林业科技支撑项目(内林科研\[2019\]003号)；中央财政林业科技推广示范项目（内林科推\[2020\]03号） |
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| Abstract: |
| The toxicity on SD pregnant rats and teratogenicity in fetal rats of Xanthoceras sorbifolium Bunge. seed oil were studied. With peanut oil as negative control and cyclophosphamide as positive control, 0.92, 1.83 g/kg and 3.67 g/kg of X. sorbifolium Bunge. seed oils were used as the low, middle and high groups to administrate SD pregnant rats, and the pregnant rats embryo toxicity indexes and fetal rats growth and development indexes were observed by anatomy, and the effects of X. sorbifolium Bunge. seed oil on the appearance deformity, bone development and internal organ and brain development of fetal rats were analyzed. The results showed that the diet and activity of pregnant rats in each dose group of X. sorbifolium Bunge. seed oil were normal, and no poisoning characteristics appeared. The weight of pregnant rats in each dose group was not affected. Compared with the negative control group, the weight gain, uterine continuous fetal weight, net weight gain, corpus luteum number, implantation number, live fetus number, absorbed fetus number and stillbirths number of pregnant rats in each dose group had no significant difference（P>0.05）. There was no significant difference in the weight, body length, appearance deformity rate, bone development deformity rate and visceral and brain development deformity rate of fetal rats in each dose group （P>0.05）. No harmful effects (NOAEL) of X. sorbifolium Bunge. seed oil was observed at 3.67 g/kg, and there was no obvious maternal toxicity, embryo toxicity and teratogenicity to SD rats. |
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