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| 1-月桂酸-3-棕榈酸甘油二酯纳米结构脂质载体对麝香草酚的包埋与缓释特性 |
| Encapsulation and slow release characteristics of thymol loaded nanostructured lipid carriers with 1-laurin-3-palmitin as solid matrix |
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| DOI： |
| 中文关键词: 1,3-甘油二酯 葵花籽油 纳米结构脂质载体 麝香草酚 缓释 |
| 英文关键词:1,3-diacylglycerol sunflower seed oil nanostructured lipid carrier thymol slow release |
| 基金项目:湖北省技术创新专项重大项目（2019ABA105）；国家自然科学基金（32072134） |
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| 中文摘要: |
| 为了开发基于功能性脂质1,3-甘油二酯的纳米结构脂质载体，研究了以1-月桂酸-3-棕榈酸甘油二酯和葵花籽油分别为固液脂质基质的纳米结构脂质载体对麝香草酚的包埋及缓释特性。结果表明：吐温-80与大豆卵磷脂质量比为1∶ 1时能很好地稳定1-月桂酸-3-棕榈酸甘油二酯与葵花籽油复合的纳米结构脂质载体，1-月桂酸-3-棕榈酸甘油二酯与葵花籽油质量比为4∶ 1、1∶ 1、1∶ 4条件下均能高效包埋麝香草酚，且载药率大于95%，但仅两者质量比4∶ 1条件下能使麝香草酚的载药量达到脂质质量的20%，并具有很好的稳定性；FTIR、荧光光谱和TEM表征表明包埋麝香草酚的1-月桂酸-3-棕榈酸甘油二酯纳米结构脂质载体具有很好的分散性和均一度；缓释实验表明，更高含量的1-月桂酸-3-棕榈酸甘油二酯会减慢麝香草酚的释放速率，可通过调节1-月桂酸-3-棕榈酸甘油二酯与葵花籽油的质量比达到控释效应。 |
| 英文摘要: |
| To develop functional lipid 1,3-diacylglycerols based nanostructured lipid carriers (NLCs), the encapsulation and slow release characteristics of thymol loaded NLCs with 1-laurin-3-palmitin as solid matrix and sunflower seed oil as liquid matrix were studied. The results showed that Tween-80 and soybean lecithin in a mass ratio of 1∶ 1 could be used to stabilize the NLCs, and the NLCs could high efficiently encapsulate thymol with the encapsulation efficiency of above 95% at three different mass ratios of 1-laurin-3-palmitin to sunflower seed oil (4∶ 1, 1∶ 1 and 1∶ 4), but the loading capacity of thymol could reach 20% of mass lipids in a mass ratio of 4∶ 1. FTIR, fluorescence spectroscopy and TEM results showed that the thymol loaded nanostructured lipid carriers had good dispersion and homogeneity. Slow release experiment of thymol showed that higher content of 1-laurin-3-palmitin could slow the release rate of thymol, which indicated that the controlled release could be achieved by adjusting the mass ratio of 1-laurin-3-palmitin to sunflower seed oil. |
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