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| Preparation and stability of snake oil nanoemulsion |
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| DOI： |
| KeyWord:snake oil nanoemulsion preparation stability particle size PDI Zeta potential |
| FundProject:吉林省重点科技研发项目（20180201007YY） |
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| Abstract: |
| The snake oil nanoemulsion was prepared by water phase titration. The effects of mixed oil phase, surfactant and cosurfactant on the preparation of snake oil nanoemulsion were studied. The pseudo three phase diagram method was used to determine the optimal formula of snake oil nanoemulsion. The results showed that snake oil and isopropyl myristate (IPM) were selected as the mixed oil phase, Span80 and Tween80 with mass ratio of 27∶ 73 as the surfactants, PEG400 as the cosurfactant.The optimal formula of smake oil nanoemulsion was obtained as follows: snake oil 1.6 g, IPM 2.4 g, Span80 1.08 g, Tween80 2.92 g, PEG400 4.0 g and water 8.0 g. The snake oil nanoemulsion was O/W type. The average partical size, PDI and Zeta potential of snake oil nanoemulsion were 63.01 nm, 0.226 and -19 mV, respectively, and the droplet appearance was round, the partical size was uniform and in good state. After centrifugation, snake oil nanoemulsion was clear and transparent without stratification. It was not resistant to high temperature and needed storing below 25 ℃. After freezing, it could be restored to its original state at room temperature. Its oxidation stabilty was higher than snake oil. |
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