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| 藻油及其与火麻仁油混合物辅助降血脂功能 |
| Assisted-hypolipidemic function of algal oil and its mixture with hemp seed oil |
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| DOI： |
| 中文关键词: 藻油 降血脂 火麻仁油 高脂血症 |
| 英文关键词:algae oil blood lipid reduction hemp seed oil hyperlipidemia |
| 基金项目: |
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| 中文摘要: |
| 研究了藻油及其与火麻仁油混合物的辅助降血脂作用。将84只SPF级雄性SD大鼠分为7组，其中6组喂养高脂高胆固醇饲料2周以建立高脂血症模型，造模成功后即进行4周干预实验，阴性对照组与模型组给予0.85％生理盐水，药物组每日灌胃3.33 mg/kg立普妥，混合物组每日灌胃800 mg/kg藻油混合物，藻油干预组每日分别灌胃150、300、600 mg/kg藻油。实验过程记录大鼠的体重、进食量与饮水量，实验结束后采集大鼠的血液、附睾脂肪、肝脏，检测大鼠的血脂四项血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)，并进行肝脏与附睾脂肪病理检测。结果表明：造模后高脂血症大鼠的TC、TG、LDL-C水平显著上升；中、高剂量藻油及其混合物均可使大鼠血清TC（混合物除外）、TG、LDL-C水平显著降低，藻油呈现剂量依赖；藻油及其混合物干预后大鼠肝脏中含脂滴的肝细胞和多灶性泡沫细胞聚集例数减少。说明藻油及其混合物对高脂高胆固醇饮食导致的肝细胞脂肪变性、脂肪堆积有一定改善作用，藻油及其混合物均有辅助降血脂作用。 |
| 英文摘要: |
| The assisted-hypolipidemic effect of algae oil and its mixture with hemp seed oil was studied. 84 SPF male SD rats were divided into 7 groups, of which 6 groups were fed with a high-fat diet for 2 weeks to establish a hyperlipidemia model. After the hyperlipidemia model was established, intervention test was carried out in the following 4 weeks. The negative control group and the model group were given 0.85% normal saline, the drug group was administrated with 3.33 mg/kg Lipitor daily, and the mixture group was administrated with 800 mg/kg algal oil mixture daily, algae oil intervention group was administrated with 150, 300, 600 mg/kg algae oil daily. During the experiment, the body weight, food intake and water intake of the rats were recorded. After the experiment, the blood, epididymal fat and liver of the rats were collected. The fouritems, the total cholesterol (TC), triglycerides(TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in serum of the rats were detected, and the pathological examination of liver and epididymal fat was conducted. The results showed that the levels of TC, TG and LDL-C in hyperlipidemia rats increased significantly. Medium and high doses of algae oil and its mixtures could significantly reduce blood TC (except the mixture group), TG and LDL-C levels, and the effect of algal oil was dose-dependent. After the intervention of algae oil and its mixture, the number of multifocal foam cell aggregates observed in the liver cells and tissues containing lipid droplets reduced. Algae oil and its mixture had a certain improvement effect on fat degeneration and fat accumulation in liver cells caused by high-fat diet. Both algae oil and its mixture with hemp seed oil had assisted-hypolipidemic effect. |
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