| The assisted-hypolipidemic effect of algae oil and its mixture with hemp seed oil was studied. 84 SPF male SD rats were divided into 7 groups, of which 6 groups were fed with a high-fat diet for 2 weeks to establish a hyperlipidemia model. After the hyperlipidemia model was established, intervention test was carried out in the following 4 weeks. The negative control group and the model group were given 0.85% normal saline, the drug group was administrated with 3.33 mg/kg Lipitor daily, and the mixture group was administrated with 800 mg/kg algal oil mixture daily, algae oil intervention group was administrated with 150, 300, 600 mg/kg algae oil daily. During the experiment, the body weight, food intake and water intake of the rats were recorded. After the experiment, the blood, epididymal fat and liver of the rats were collected. The fouritems, the total cholesterol (TC), triglycerides(TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in serum of the rats were detected, and the pathological examination of liver and epididymal fat was conducted. The results showed that the levels of TC, TG and LDL-C in hyperlipidemia rats increased significantly. Medium and high doses of algae oil and its mixtures could significantly reduce blood TC (except the mixture group), TG and LDL-C levels, and the effect of algal oil was dose-dependent. After the intervention of algae oil and its mixture, the number of multifocal foam cell aggregates observed in the liver cells and tissues containing lipid droplets reduced. Algae oil and its mixture had a certain improvement effect on fat degeneration and fat accumulation in liver cells caused by high-fat diet. Both algae oil and its mixture with hemp seed oil had assisted-hypolipidemic effect. |
