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| Effects of Antarctic krill lipids on C57BL/6J mice administrated palm oil-based polar substances |
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| DOI： |
| KeyWord:Antarctic krill lipid palm oil polar substance C57BL/6J mice |
| FundProject:无锡商业职业技术学院博士科研启动经费（RSI9BS02）；2019年校级课题（KJXJ19602） |
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| Abstract: |
| A C57BL/6J mice model of high-fat diet (palm oil and palm oil-based polar substance (TPC)) was established, and the effect of the Antarctic krill lipids on the growth and development, fat and glucose metabolism in mice were studied. The results indicated that palm oil and TPC were more easily lead to obesity, The contents of TC, TG, LDL-C, MDA and the activities of ALT and AST in serum, and the content of MDA in liver increased significantly, while the content of HDL-C in serum and SOD activity in liver decreased significantly. The area under the curve of the blood glucose(AUC) increased significantly within 120 min of glucose injection. Antarctic krill lipids had a positive effect on weight control of mice intaking palm oil, and significantly reduced the contents of TC, LDL-C, MDA in the serum and the content of MDA in the liver of mice intaking palm oil and palm oil-based polar substances, and significantly improved the activity of SOD in the liver and the AUC within 120 min of subcutaneous injection of glucose. Palm oil and palm oil-based polar substances could cause disorders of lipid and glucose metabolism in mice, and increase the risk of cardiovascular disease and diabetes in mice, while Antarctic krill lipids could reduce the risks caused by intaking of palm oil and palm oil-based polar substances. |
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