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| Protective effect of corn peptide on alcoholic brain injury in mice and its mechanism |
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| DOI： |
| KeyWord:corn peptide alcohol brain injury oxidative stress proinflammatory cytokine |
| FundProject:黑龙江省省属高等学校基本科研业务费科研项目（135409407）；齐齐哈尔大学研究生创新科研项目（YJSCX 2020026）；黑龙江省青年科学基金（QC2018028） |
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| Abstract: |
| The alcoholic brain injury mouse model was established, and the protective effect of corn peptide on the alcoholic brain injury was studied. ICR mice were randomly divided into 5 groups: normal control group, alcohol model group, high dose corn peptide group(2 g/kg), medium dose corn peptide group(1 g/kg) and low dose corn peptide group(0.5 g/kg). The alcoholic brain injury mouse model was induced by drinking alcoholic solution, then the mice in the experimental group were given corn peptide for 5 months. The brain tissue was taken for histopathological observation and ELISA mensuration, including oxidative stress-related indicators, inflammatory cytokines levels and some apoptosis-related indicators. The results showed that the histopathology indicated that the alcoholic brain injury was reduced to different degree in low, medium and high dose corn peptide groups. The results of oxidative stress indexes indicated that corn peptide could increase the content of GSH and the activities of GSH-Px and T-SOD, and decrease the contents of MDA and ROS （P<0.05）. In addition, the levels of TNF-α, IL-6, IFN-γ, TGF-β1 and NF-κB in brain tissue were significantly decreased （P<0.05） by corn peptide. In conclusion, corn peptide ameliorated alcoholic brain damage not only by regulating oxidative stress of nerve cell, but also by reducing proinflammatory cytokines levels. |
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