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| Effect of pumpkin seed sterol on benign prostatic hyperplasia and antioxidant capacity of rats |
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| DOI： |
| KeyWord:pumpkin seed sterol rat benign prostatic hyperplasia antioxidant capacity |
| FundProject:黑龙江省宝清县人民政府科研项目(SYSBQXZF-20171101) |
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| Abstract: |
| The extracted and purified pumpkin seed sterol was used to feed the rats with benign prostate hyperplasia induced by testosterone propionate to study its effect on the benign prostate hyperplasia and antioxidant capacity of rats. 50 Male SD rats were divided into control group, model group, high, medium and low dose groups of pumpkin seed sterol. After the experiment, the prostate wet weight, prostate index (PI), and levels of prostatic acid phosphatase (PACP), total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured, the morphology of prostate tissue was observed simultaneously. The results showed that compared with the model group, the wet weight, PI, PACP activities, and MDA content of the high dose group of pumpkin seed sterol significantly decreased, and the T-AOC level and SOD activity in the midium and high dose groups of pumpkin seed sterol significantly increased. All of the above changes showed a trend of high dose group of pumpkin seed sterol better than medium dose group. At the same time, the prostate tissue cell damages of rats in medium and high dose groups of the pumpkin seed sterol were improved compared with the model group, and high dose group of the pumpkin seed sterol had the most obvious effect. This indicated that pumpkin seed sterol improved the prostate hyperplasia in rats to some extent and improved the antioxidant capacity of rat prostate tissue. |
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