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| Main bioactive compositions of oil-tea camellia seed cake extract and its effect on cadmium induced learning-memory impairment in rats |
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| DOI： |
| KeyWord:cadmium oil-tea camellia seed cake extract oxidative stress learning-memory |
| FundProject:江西省教育厅科学技术研究项目（GJJ201547，GJJ190814）；赣南医学院科研课题（YB201818，ZD201907） |
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| Abstract: |
| The main bioactive compositions of oil-tea camellia seed cake extract and its effect on protecting organs against oxidative stress and ameliorating the learning-memory impairment induced by cadmium were explored. UPLC MS/MS was used to analyze the main bioactive compositions. Nine-week old SD rats were randomly divided into control group (0.9% NaCl administration+0.9% NaCl intraperitoneal injection), exposure group (0.9% NaCl administration+0.1% CdCl2 intraperitoneal injection) and intervention group (1% oil-tea camellia seed cake extract administration+0.1% CdCl2 intraperitoneal injection). And the rate were fed by daily gavage and 3 d intraperitoneal injection with 1 d off for 31 d, then the Morris water maze test was used to assess the learning-memory function of the rats in the different groups, and the organ coefficients were calculated, and indicators of oxidation, including glutathione peroxidase (GSH-Px) activity, superoxide dismutase (SOD) activity and malondialdehyde (MDA) content of serum, kidney, liver and brain were determined. The results showed that oil-tea camellia seed cake extract contained 15 kinds of bioactive components. Compared with the control group, the organ coefficient of kidney and liver in the exposure group rats increased very significantly (P<0.001), the activities of serum GSH-Px and liver SOD decreased very significantly (P<0.001) and significantly (P<0.05) respectively, and the latency of looking for platform was prolonged significantly (P<0.05). After the intervention of oil-tea camellia seed cake extract, these indexes were restored to a certain extent. Therefore, oil-tea camellia seed cake extract could inhibit cadmium induced oxidative stress and learning-memory impairment to a certain extent. |
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