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| Ameliorative effects of corn peptide on cognitive impairment in mice with chronic alcoholism |
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| DOI： |
| KeyWord:corn peptide alcohol cognitive impairment neurotransmitter improvement |
| FundProject:黑龙江省青年科学基金项目（QC2018028）；黑龙江省省属高等学校基本科研业务费科研项目（135409407）；齐齐哈尔大学研究生创新科研项目（YJSCX2020026）；中央支持地方高校发展改革资金高水平人才项目（2020GSP08） |
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| Abstract: |
| The effect of corn peptide on cognitive impairment in mice with chronic alcoholism was studied. Eighty ICR mice were randomly divided into five groups: normal control group, chronic alcoholic brain injury model group (alcohol model group), high dosage corn peptide group(2 g/kg), medium dosage corn peptide group(1 g/kg) and low dosage corn peptide group(0.5 g/kg). First, the tests of neurobehavior (Morris water maze and passive avoidance test) were conducted, the levels of dopamine (DA), 5-hydroxytryptamine(5-HT), γ-aminobutyric acid(GABA) and the activities of acetylcholinesterase(AChE) and nitric oxide synthetase (NOS) in brain tissue of mice were detected, and then the brain hippocampal tissue was taken for histopathological observation. The results showed that in the Morris water maze test, compared with the alcohol model group, the escape latency of mice in the midium and high dosage corn peptide groups was significantly shorter and the crossing times significantly increased in the effective area（P<005）; the crossing time in the effective area in the midium dosage corn peptide group significantly increased （P<0.05). The passive avoidance test showed that corn peptide could significantly decrease the number of errors and increase the escape latency (P<0.05). Histopathology showed that midium and high dosage groups of corn peptide could reduce the damage of alcohol to hippocampus in different degree. It was found that corn peptide could modulate the levels of 5-HT, DA and NOS in the brain after drinking, but could not decrease the levels of AChE and GABA induced by alcohol. In conclusion, corn peptide can improve the cellular and synaptic dysfunction caused by the disorder of some related neurotransmitters in the brain tissue of mice after drinking, so as to reduce the cognitive impairment caused by alcohol. |
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