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| Preliminary toxicological study of compound Elaeagnus mollis seed oil |
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| DOI： |
| KeyWord:compound Elaeagnus mollis seed oil acute toxicity inherent toxicity sub-acute toxicity |
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| Abstract: |
| To study the safety of compound Elaeagnus mollis seed oil(blend oil of Elaeagnus mollis seed oil and grape seed oil), maximum tolerated dose(MTD) was used to observe acute toxicity of compound Elaeagnus mollis seed oil, and Ames test,bone marrow polychromatic erythrocyte micronucleus test and mice sperm abnormality test were used to study the inherent toxicity,and the sub-acute toxicity test was used to study the sub-acute toxicity of compound Elaeagnus mollis seed oil.The results showed that the oral MTD of compound Elaeagnus mollis seed oil in male and female mice was above 20.0 g/kg. The result of inherent toxicity test was negative. There was no evident sub-acute toxicity in each dose group.So compound Elaeagnus mollis seed oil belonged to non-toxic grade and had no significant inherent toxicity or sub-acute toxicity. |
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