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| Advance in metabolic engineering for bioconversion of phytosterols into steroid metabolites by Mycobacterium sp. |
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| DOI： |
| KeyWord:Mycobacterium sp. phytosterols bioconversion steroid metabolites metabolic pathway metabolic engineering |
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| Abstract: |
| Steroid hormone drug is an important category in the pharmaceutical industry, and is the second largest drug after antibiotic. The synthesis of almost all steroid hormone drug starts from the quality production of steroid metabolites such as AD, ADD, 9α-OH-AD and 4-BNA. Bioconversion of phytosterols into steroid metabolites has become the mainstream of industrial production of steroid drugs. The metabolic pathway, key enzymes and molecular mechanism involved in phytosterols degradation by Mycobacterium sp. were reviewed, and the research progress on using genetic engineering technology to modify the phytosterol metabolic pathway of Mycobacterium sp. to accumulate target steroid metabolites in recent years were summarized. The future research direction was predicted in order to provide a valuable reference for the green biological manufacture of steroid metabolites. |
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