|
| Effect of Moringa oleifera seed extract on blood lipid and liver in hyperlipidemia mice |
| |
| DOI： |
| KeyWord:hyperlipidemia Moringa oleifera seed extract blood lipid liver farnesoid X receptor |
| FundProject: |
| Author Name | Affiliation | | WANG Hong1, LIU Yue1, RAO Lu1，CAI Rongshan1, SONG Tingting1,HE Zhendan2, XU Yingshu1,XIONG Yong′ai1 | 1.College of Pharmacy, Zunyi Medical University, Zunyi 563000,Guizhou, China
2.College of Pharmacy, Shenzhen Technical University, Shenzhen 518118, Guangdong, China |
|
| Hits: 1222 |
| Download times: 869 |
| Abstract: |
| By gavage of Moringa oleifera seed extract to hyperlipidemia mice model, the effects of Moringa oleifera seed extract on blood lipid and liver in hyperlipidaemia mice were studied. Sixty KM mice were randomly divided into control group, model group, simvastatin group (1 mg/kg), Moringa oleifera seed extract low (5 mg/kg), medium (10 mg/kg) and high (20 mg/kg) dose groups according to body mass, 10 mice in each group. Except for the control group fed the basic feed, the other groups were given high-fat diet. At the sixth week, except for the control group and the model group, the mice in other groups were given the drugs correspondingly in serum for three weeks. The HDL-C, LDL-C, TG and TC levels in serum of mice were measured at the end of the experiment. The liver index and pathomorphology were detected and the farnesoid X receptor（FXR） protein expression in liver were determined by immunohistochemistry. The results showed that the low, medium and high dose Moringa oleifera seed extract significantly reduced TG, TC and LDL-C levels(p<0.05) and increased HDL-C levels(p<0.01)in serum of hyperlipidemia mice, significantly improved the pathological morphology of liver, markedly reduce the liver pathology score(p<0.01), low dose Moringa oleifera seed extract could remarkably reduce the liver index(p<0.05), and low and high dose Moringa oleifera seed extract significantly reduced the FXR protein expression in liver (p<0.05). Moringa oleifera seed extract has significant therapeutic effects in hyperlipidemic mice, and its mechanism may be related to the down-regulation of FXR protein expression in liver. |
| View full text View/Add Comment Download reader |
| Close |
|
|
|
