| In order to further develop and applicate Acertruncatum seed oil, the effects of Acertruncatum seed oil on lipid metabolism and intestinal health of high-fat diet mice were studied. The mice were divided into blank group, model group, high dose group 〔1 200 mg/(kg·d)〕 and low dose group 〔600 mg/(kg·d)〕, and were gavaged continuously for 60 d. After the experiment, the growth status, lipid level in serum,caecal metabolites microenviromental indexes, short chain fatty acids content and microflora of the mice were measured. The results showed that compared with the model group, high dose group of Acertruncatum seed oil could significantly reduce the body weight, waist circumference, Lee′s index, abdominal fat mass, the contents of free ammonia, ammonia nitrogen, hydrogen sulfide and pH in caecum metabolites, and remarkably increase the contents of butyric acid, valerate acid and propionic acid in caecum metabolites. The low and high dose groups of Acertruncatum seed oil could significantly decrease the contents of serum triglyceride (TG) and total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), remarkably increase the content of high-density lipoprotein cholesterol(HDL-C), beneficial microorganisms and inhibit the effect of harmful bacteria in intestinal tract. Therefore, Acertruncatum seed oil can improve the derangement of lipid metabolism and promote intestinal health in mice caused by high-fat diet. |
