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| 元宝枫籽油对高脂膳食小鼠脂代谢及肠道健康的影响 |
| Effects of Acertruncatum seed oil on lipid metabolism and intestinal health of high-fat diet mice |
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| DOI： |
| 中文关键词: 元宝枫 元宝枫籽油 脂代谢 肠道健康 |
| 英文关键词:Acertruncatum Acertruncatum seed oil lipid metabolism intestinal health |
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| 中文摘要: |
| 为了进一步开发与应用元宝枫籽油，研究了元宝枫籽油对高脂膳食小鼠脂代谢及肠道健康的影响。将60只小鼠分为空白组、模型组、元宝枫籽油高剂量组〔1 200 mg/(kg·d）〕和低剂量组〔600 mg/(kg·d）〕，连续灌胃60 d。实验结束后，测定小鼠生长状况、血脂水平、盲肠微环境指标和盲肠内容物短链脂肪酸及微生物菌群。结果表明：与模型组相比，元宝枫籽油高剂量组能显著降低小鼠体质量、腰围、Lee′s指数、腹腔脂肪质量，显著降低小鼠盲肠内容物中游离氨、氨态氮、硫化氢和pH，显著增加盲肠内容物中丁酸、戊酸和丙酸的含量；元宝枫籽油高、低剂量组可显著降低小鼠血清中甘油三酯（TG）、总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的水平，显著升高高密度脂蛋白胆固醇（HDL-C）水平，显著促进肠道有益微生物的生长，抑制有害菌的生长。因此，元宝枫籽油具有改善因高脂膳食引起的小鼠脂代谢紊乱和促进肠道健康的作用。 |
| 英文摘要: |
| In order to further develop and applicate Acertruncatum seed oil, the effects of Acertruncatum seed oil on lipid metabolism and intestinal health of high-fat diet mice were studied. The mice were divided into blank group, model group, high dose group 〔1 200 mg/(kg·d)〕 and low dose group 〔600 mg/(kg·d)〕, and were gavaged continuously for 60 d. After the experiment, the growth status, lipid level in serum,caecal metabolites microenviromental indexes, short chain fatty acids content and microflora of the mice were measured. The results showed that compared with the model group, high dose group of Acertruncatum seed oil could significantly reduce the body weight, waist circumference, Lee′s index, abdominal fat mass, the contents of free ammonia, ammonia nitrogen, hydrogen sulfide and pH in caecum metabolites, and remarkably increase the contents of butyric acid, valerate acid and propionic acid in caecum metabolites. The low and high dose groups of Acertruncatum seed oil could significantly decrease the contents of serum triglyceride (TG) and total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), remarkably increase the content of high-density lipoprotein cholesterol(HDL-C), beneficial microorganisms and inhibit the effect of harmful bacteria in intestinal tract. Therefore, Acertruncatum seed oil can improve the derangement of lipid metabolism and promote intestinal health in mice caused by high-fat diet. |
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