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| Effect of sesame paste on osteoporosis of rats induced by bilateral ovariectomy |
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| DOI： |
| KeyWord:sesame paste ovariectomy female rat osteoporosis |
| FundProject: |
| Author Name | Affiliation | | QIU Min1,2,WANG Huimin1,2,LU Jie1,ZHAO Leizhen1,2,REN Changbo3,YUAN Wenpeng1,2 | 1.Heze Branch of Shandong Academy of Sciences，Qilu University of Technology (Shandong Academy of Sciences),Heze 274000, Shandong, China
2.Biological Engineering Technology Innovation Center of Shandong Province, Heze 274000,Shandong, China
3.Shandong Shilixiang Sesame Products Co. , Ltd. , Binzhou 256600,Shandong, China |
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| Abstract: |
| In order to understand whether sesame paste had calcium supplement effect, the effect of sesame paste on osteoporosis of female rats induced by bilateral ovariectomy was investigated. Healthy female SD rats were selected as the research objects, except for the sham operation group, the rest rats were all removed the bilateral ovaries to establish a female rat osteoporosis model. After successful modeling, the ovariectomized rats were randomly divided into model group, calcium gluconate group〔0.56 g/(kg·d)〕, and the low〔1.04 g/(kg·d)〕, middle〔2.08 g/(kg·d)〕 and high〔4.16 g/(kg·d)〕doses groups of sesame paste. After 12 weeks of intragastric administration of normal saline, calcium gluconate, and sesame paste, the effects of sesame paste on the body weight, organ coefficient, serum biochemical indicators, bonestrength, bone calcium content, and bone tissue morphology of rats were tested. The results showed that after the removal of the ovaries for 12 weeks, compared with the sham operation group, the body weight of ovariectomized rats was significiently increased (p＜0.01), the uterine shape was significantly atrophy, and the osteoporosis was significantly increased, indicating that the model was successfully constructed. After 12 weeks of continuous administration of sesame paste, compared with the model group, sesame paste did not significantly affect the body weight, organ coefficient, bone strength, bone calcium content and bone tissue structure of bilateral ovariectomized rats, low and middle dose of sesame paste could significantly increase the level of serum phosphorus of rats (p＜0.01) and significantly reduce the level of serum alkaline phosphatase of rats(p＜0.05), the middle dose of sesame paste could significantly increase the serum calcium level of rats (p＜0.01), and the high dose of sesame paste could significantly increase the serum phophorus level (p＜0.05), while sesame paste had no significant effects on serum total cholesterol, triglycerides, and high-density lipoprotein cholesterol. Therefore, sesame paste could improve the blood indicators related to bone metabolism in bilateral ovariectomized rats to a certain extent, but its effect on the skeletal system was not significant. |
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