|
| Protective effect of corn peptide on alcohol-induced brain damage in rats |
| |
| DOI： |
| KeyWord:corn peptide alcohol brain damage |
| FundProject: |
|
| Hits: 2083 |
| Download times: 2575 |
| Abstract: |
| In order to develop the natural active peptide with the function of preventing alcoholic brain damage, SD rats were randomly divided into 7 groups, control group, model group, and 125, 250, 500, 1 000 mg/kg and 2 000 mg/kg corn peptide experimental groups, and the chronic alcoholism brain damage model in rats was established by administration of 50% Beidachang liquor. After modelling, the brain tissue was taken for histopathological observation and ELISA mensuration, including oxidative stress, inflammatory cytokines levels, some neurotransmitters and other related indicators. The results showed that alcohol could induce pathological changes of nerve cells in brain tissue, and the intervention of corn peptide could effectively relieve the damage of brain tissue. Corn peptide could reduce ROS and improve GSH levels, recover GST and GSH-Px activity in brain tissue of rats after drinking, and reduce the levels of NF-κB, TNF-α, IL-1, IFN-γ and TGF-β1 in brain tissue. Corn peptide also had positive effects on the activation of Caspase-3 and regulate some neurotransmitters in brain tissue of rats with chronic alcoholism. In conclusion, corn peptide has protective effects on chronic alcoholism brain damage in rats. |
| View full text View/Add Comment Download reader |
| Close |
|
|
|
