|
| Short-term toxicity test of red palm oil |
| |
| DOI： |
| KeyWord:red palm oil short-term toxicity test safety evaluation |
| FundProject: |
| Author Name | Affiliation | | LI Hanling1, LU Huiyuan1, SHEN Weijian1, YOONG Junhao2 , NIU Yueting2, SU Zhitong1, LI Rongrong1,ZHAO Xiaona1, LONG Yunfeng1, ZHOU Ping1, WANG Yiqian1 | 1.Animal, Plant, and Food Inspection Center of Nanjing Customs, Nanjing 210001, China
2.Palm Oil Research and Technical Service Institute of Malaysian Palm Oil Board, Shanghai 201108, China |
|
| Hits: 2119 |
| Download times: 2509 |
| Abstract: |
| In order to evaluate the safety of red palm oil as cooking oil, the short-term toxicity test of red palm oil from Malaysia was conducted by GB 15193.22-2014 National food safety standard 28-day oral toxicity test. A total of 100 SD rats were devided into 5 groups, and the high, medium, low dose groups of red palm oil were set according to 20.48, 10.24, 5.12 times of human intake. Solvent control group (corn oil group) and negative control group (palm oil group) were also set. The rats were given both adulterated feed and oral gavage for 28 d. The clinical performance of the rats was observed daily, body weight and food intake were recorded weekly, and food utilization was calculated. Before and at the end of the test, rats′ eyes were examed. At the end of the test, the tests of hematology, blood biochemistry, routine urine, gross anatomy and histopathological examination were carried out on the main organs, and the organ coefficient was calculated. The results showed that giving red palm oil at the real dose of female 2.04, 4.11 g/kg and 8.31 g/kg and male rats 2.12, 4.23 g/kg and 8.45 g/kg for 28 d, the experimental rats were in good clinical performance, with no abnormal changes in body weight, food utilization, organ weight and organ coefficient. The results of hematology and biochemistry and routine urine indexes were within the normal range. The histopathological examination of each organ showed no pathological changes related to the tested sample.The red palm oil has no harmful effects on rat, and is safe for orally intake in a short period of time. |
| View full text View/Add Comment Download reader |
| Close |
|
|
|
