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| Determination of 14 kinds of metal elements in soybean oil (for injection) by microwave digestion-inductively coupled plasma mass spectrometry |
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| DOI： |
| KeyWord:soybean oil (for injection) inductively coupled plasma mass spectrometry (ICP-MS) microwave digestion metal element |
| FundProject: |
| Author Name | Affiliation | | CHEN Qiuling, LI Yonghua,WANG Xiaomei, XU Wendong, LIN Yuanheng,ZHU Zhiqi, LIANG Beimei, WEN Kaijia, XU Yijing, TANG Shunzhi | Guangdong Key Laboratory of Medicinal Lipids, National Engineering Research Center (NERC) for Modernization of Extraction and Separation Process of TCM, Guangzhou Hanfang Pharmaceutical Co. ,Ltd. ,Guangzhou 510240,China |
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| Abstract: |
| Aming at providing reference for the safety control and security evaluation of soybean oil (for injection), a method for the determination of metal elements content in soybean oil (for injection) by microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS) were developed. 0.5 g soybean oil (for injection) was dissolved in nitric acid and then predigested at 100 ℃ for 1 h, pretreated in microwave digestion instrument and measured with ICP－MS under the conditions of radio frequency power 1 550 W, flow rate of carrier gas (high purity argon) 1.03 L/min, flow rate of plasma gas 15.0 L/min, peristaltic pump speed 0.1 r/s and sampling depth 10 mm to determine the content of 14 kinds of metal elements. The use of quadrupole collision/reaction cell technology could eliminate the interference of polyatomic ions with the elements to be measured. Scandium (Sc), germanium (Ge), indium (In) and rhenium (Re) were used as internal standards to correct matrix interference and drift. The results showed that the detection limits of 14 kinds of metal elements were in the ranges of 0.004-0.283 ng/mL.The quantitation limits were 0.012-0.945 ng/mL.The linear relationship for the elements was good with the correlation coefficients being all above 0.999．The precision of the instrument was good and RSD were 0.38%-5.03%. The repeatability RSD were 1.02%-4.62%. The intermediate precision RSD were 1.40%-16.21%. The stability of the sample solution was good when it was stored at 2-8℃ for 3 d, with RSD in the range of 0.54%-9.61%. The recoveries of the 14 kinds of metal elements at three levels（low, medium and high）were 78.87%-112.07% and the RSD were 1.37%-7.08%. In summary, the method is rapid, accurate and sensitive, and it can be used for the simultaneous detection of 14 kinds of metal elements in soybean oil (for injection). |
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