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| Effects of enzymatic cyclodextrin synthesis-tributyrin inclusion complex on growth performance, antioxidant function and intestinal health of mice |
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| DOI： |
| KeyWord:cyclodextrin tributyrin growth performance antioxidant intestinal health |
| FundProject:国家自然科学基金项目(32072171) |
| Author Name | Affiliation | | FENG Yan1, LI Zhaofeng1,2, GU Zhengbiao1,2, BAN Xiaofeng1,
KONG Haocun1, LI Caiming1,2 | 1.School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
2.State Key
Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China |
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| Abstract: |
| In order to clarify the biological effectiveness of enzymatic cyclodextrin synthesis-tributyrin inclusion complex (ECT) in animals and provide theoretical guidance for its application in animal feed, 36 3-week-old BALB/c male mice were randomly divided into 6 groups: control group, tributyrin group, enzymatic cyclodextrin group, maltodextrin-tributyrin complex group, silica-tributyrin group, and ECT group. After 5 weeks of feeding, the body weight, serum biochemical indexes, liver antioxidant indexes, villus height and crypt depth of small intestine, colon length, colonic histological injury score, colonic goblet cell number and short-chain fatty acid contents in faeces were measured to explore the effects of ECT on the growth performance, antioxidant function and intestinal health of mice. The results showed that compared with the control group, the ECT group increased the average daily weight gain by 88.37%, reduced the feed/gain by 45.01%, reduced the serum triglyceride content by 38.88%, increased the total antioxidant activity by 3645%, reduced the colonic histological injury score, and increased the number of goblet cells in colon tissue by 23.44%. Total short-chain fatty acids and butyric acid contents in faeces increased by 64% and 196%, respectively. In conclusion, ECT can improve the growth performance and feed utilization rate of mice, improve the antioxidant capacity of the liver, promote the development of the small intestine, increase the content of short-chain fatty acids such as butyric acid in the intestine, prevent colon inflammation, and benefit intestinal health. ECT has the application potential as a nutritional feed additive. |
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