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Mechanism of action of Koelreuteria bipinnata seed oil in the treatment of fatty liver based on network pharmacology and molecular docking
  
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KeyWord:Koelreuteria bipinnata seed oil  fatty liver  network pharmacology  molecular docking
FundProject:教育部“春晖计划”合作科研项目（14）；陕西省教育厅青年创新团队科研计划项目（22JP076）
Author NameAffiliation
ZHENG Lei1，2，ZHAO Ziyue1，YANG Wentao1，HE Hao1,2，ZHANG Cunlao1，XU Yue1，2 1.College of Pharmacy, Xi′an Medical University, Xi′an 710021, China
2.Shaanxi Provincial Key Laboratory of Food and Drug Safety Monitoring，Xi′an 710065, China 
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Abstract:
      In order to investigate the possible pharmacological basis, potential targets and mechanism of action of the active ingredients of Koelreuteria bipinnata seed oil in the treatment of fatty liver, based on network pharmacology and molecular docking, six core active ingredients in Koelreuteria bipinnata seed oil eicosenoic acid, palmitic acid, linoleic acid, oleic acid, erucic acid and arachidic acid were obtained, and 69 targets related to the treatment of fatty liver were screened, predicting the possible action on five core target proteins ALB, IGF1, PPARα, PPARγ and SRC, and the therapeutic effect of fatty liver was exerted through the interaction between active ingredients and targets. Koelreuteria bipinnata seed oil has multi-component, multi-target and multi-pathway action characteristics for the treatment of fatty liver.
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