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| Preventive effect of medium-chain triacylglycerol against negative lens- induced myopia in guinea pigs with high sucrose diet |
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| DOI： |
| KeyWord:medium-chain triacylglycerol myopia insulin resistance blood triglyceride |
| FundProject:陕西省自然科学基础研究计划项目（2022JM-571）；陕西省人民医院2021年科技发展孵化基金项目（2021YJY-20） |
| Author Name | Affiliation | | CHEN Zhuo1, SHI Rui2, TAN Liyu1, ZUO Hao3, WANG Ni3 | 1.Xi′an Medical University, Xi′an 710021, China
2.Shaanxi Provincial People′s Hospital,
Xi′an 710068, China
3.Xi′an Shi′s Optometry Company, Xi′an 710004, China |
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| Abstract: |
| In order to provide a reference for the prevention and control of myopia through nutritional means, the protective effect of medium-chain triacylglycerol (MCT) on myopia in guinea pigs with high sucrose diet was investigated. Three-week-old guinea pigs were randomly divided into MCT group, long-chain triacylglycerol (LCT) group, high sucrose (SD) group, normal diet (CD) group and control(CON) group.The first three groups fed with MCT plus high-sucrose feed, olive oil plus high-sucrose feed, simple high-sucrose feed respectively, and the CD and CON groups fed with common feed. After four weeks of feeding, the development of diopters and insulin resistance were analyzed. In the following five weeks, myopia was induced by negative lens in the right eye of each group except the CON group, and the left eye was used as its own control. After five weeks, the changes of binocular diopter and insulin resistance levels of guinea pigs in each group were measured, and the blood triglyceride levels of guinea pigs in each group were also measured. The results showed that all groups on a high-sucrose diet developed insulin resistance after four weeks, and all eyes induced by negative lenses developed high myopia after five weeks of induction. The insulin resistance and blood triglyceride levels were higher in the high-sucrose diet group than in the CON group. The diopter of the experimental eye in the high-sucrose diet group was significantly different from that in the CD group. Compared with the LCT group and SD group, the MCT group was more protected on insulin resistance, negative lens-induced myopia in the right eye, and blood triglyceride levels. In conclusion, a diet with high sucrose can cause insulin resistance in guinea pigs and exacerbate the effect of negative lens induction myopic refractive error in guinea pigs. MCT has a protective effect on lens-induced myopia in guinea pigs exacerbated by high-sucrose diet. |
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