|
| Effect of olive oil rich in zeaxanthin on hyperlipidemia mice |
| |
| DOI： |
| KeyWord:zeaxanthin olive oil hyperlipidemia mice blood glucose reduction blood lipid reduction acute and chronic toxicology |
| FundProject:2021年甘肃省科技重大专项（21ZD4NK045）；2021年甘肃省自然科学基金(21JR7RK912）；2022年甘肃省重点研发计划项目（22YF7FK220） |
| Author Name | Affiliation | | YE Wenbin1, CHEN Wendong1, WANG Rangjun1, ZHANG Kai1,
HUANG Xinyi2, DI Duolong2, WANG Yu1 | 1.School of Agriculture and Forestry Technology, Longnan Teachers College, Longnan 742500,
Gansu, China； 2.Key Laboratory of Chemistry of North Western Plant Resources ＆ Key Laboratory for
Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics,
Chinese Academy of Sciences, Lanzhou 730000, China |
|
| Hits: 1351 |
| Download times: 1421 |
| Abstract: |
| In order to provide a reference for the development of health care products of olive oil rich in zeaxanthin(ZT), the mice model of hyperlipidemia was established by intragastric administration of lipid emulsion, and the nomal saline group(CK) was set up at the same time. The successfully modeled mice were randomly divided into hyperlipidemia model group (Model), high,middle and low dosages groups of ZT,and Philbert control group(PL). The drug was given by intragastic administration continuously for 28 d to investigate the effects of ZT(zeaxanthin content 400 mg/100 g) on fasting blood glucose (FBG), glycated hemoglobin (HbAlc), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total bilirubin (TBIL), total bile acid (TBA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-ammonia acyltransferase (GGT) and alkaline phosphatase (ALP) in hyperlipemia mice, and acute and chronic toxicological studies on ZT mice were carried out. The results showed that ZT could effectively decrease the contents of FBG, HbAlc, TC, TG, LDL, TBIL, TBA, increase the content of HDL, and inhibit the activities of ALT, AST, GGT and ALP. It could significantly improve the metabolic disorder of blood glucose and lipid, and reduce the body weight of mice. It had no acute or chronic toxicity to normal mice. It could increase the activities of SOD, CAT and GSH-Px in serum of mice. Therefore, olive oil rich in zeaxanthin is a non-toxic substance, which can improve the antioxidant capacity and reduce the body weight of mice, and it is an olive oil health-care food with good auxiliary blood glucose reduction and blood lipid reduction effects. |
| View full text View/Add Comment Download reader |
| Close |
|
|
|
