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| Effect of Xanthoceras sorbifolium Bunge.oil on memory ability of male mice |
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| DOI： |
| KeyWord:Xanthoceras sorbifolium Bunge. oil nervonic acid memory ability step-down test dark avoidance test water maze test |
| FundProject:内蒙古自治区“草原英才”青年创新人才工程专项资金(2020)；内蒙古自治区林业科技支撑项目(内林科研\[2021\]12号) |
| Author Name | Affiliation | | LU Xin1,2,3, LI Xianyu2,3, TAO Chao4,5, HU Qi4,5, YANG Suzhi2,3,
WU Zhiyan3, XU Jia4,5, QI Changyong4,6, ZHANG Jingshu4,5 | 1.College of Forestry, Northeast Forestry University, Harbin 150040, China
2.Chifeng Forestry Research Institute,
Chifeng 024005,Inner Mongolia,China
3.National Forestry and Grassland Wenguan Fruit Engineering
Technology Research Center, Chifeng 024005,Inner Mongolia,China
4.School of Public Health,
Nanjing Medical University, Nanjing 211166, China
5.Safety Assessment and Research Center
for Drug, Pesticide and Veterinary Drug of Jiangsu Province, Nanjing 211166，China
6.Medical
Laboratory Animal Center, Nanjing Medical University，Nanjing 211166，China |
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| Abstract: |
| In order to provide data support for the development of Xanthoceras sorbifolium Bunge. oil related products, healthy male mice were divided into 4 groups, namely control group (corn oil), low-dose group 〔2.1 g/(kg·d)〕, medium-dose group 〔4.2 g/(kg·d)〕 and high-dose group 〔12.5 g/(kg·d)〕 of the Xanthoceras sorbifolium Bunge. oil. After one month of intragastric administration, the body weight of mice was measured, and the step-down test, dark avoidance test and water maze test were carried out to evaluate the effects of Xanthoceras sorbifolium Bunge. oil on memory ability of male mice. In addition, the contents of dopamine (DA), 5-hydroxytryptamine (5-HT), norepinephrine (NE), acetylcholine (ACh) and the activity of acetylcholinesterase (AChE) in the homogenates of hippocampus and cerebral cortex of mice were measured to explore the mechanism of the effect of Xanthoceras sorbifolium Bunge. oil on memory ability of mice. The results showed that there was no significant difference in body weight and growth rate among all groups after one month of intragastric administration test. The step-down test, dark avoidance test and water maze test were all positive. In high-dose group, the contents of 5-HT, ACh, NE and DA in homogenates of hippocampus and cerebral cortex of mice were significantly increased and the activity of AChE was significantly decreased. In summary, Xanthoceras sorbifolium Bunge. oil has the function of improving memory of mice, and it plays the role by improving the metabolism of monoamine neurotransmitters and cholinergic neurotransmitters. |
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