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| Preparation of pharmaceutical-grade micritic lanolin alcohol |
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| DOI： |
| KeyWord:pharmaceutical-grade lanolin alcohol adsorbent micritic |
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| Abstract: |
| In order to improve the added value of daily chemical-grade lanolin alcohol and improve the technical reference for the large-scale preparation of pharmaceutical-grade lanolin alcohol, the daily chemical-grade lanolin alcohol was used as the raw material, and the pharmaceutical-grade micritic lanolin alcohol was prepared by adsorbent decolorization, two-stage molecular distillation and cooled spray pelleting. The adsorbent was screened, the influence of the pelleting conditions on the pelleting rate of conformity was investigated, and the quality indexes (acid value, peroxide value, saponification value, Gardner′s color) of the produced pharmaceutical-grade micritic lanolin alcohol were determined. The results showed that AB-8 macroporous resin had good decolorization effect and high product yield. Under the conditions of cooling air temperature 10 ℃, cooling air humidity 20%, spraying pressure 0.6 MPa, and nozzle rotational speed 6 000 r/min, the pelleting rate of conformity of pharmaceutical-grade micritic lanolin alcohol reached 95.78%, and the produced pharmaceutical-grade lanolin alcohol complied with the requirements of the Pharmacopoeia of Europe and the United States for pharmaceutical-grade lanolin alcohol. In conclusion, this method can obtain qualified pharmaceutical-grade lanolin alcohol. |
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