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| Preparation and in vitro anti-inflammatory activity of genistein-loaded nanoliposomes |
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| DOI： |
| KeyWord:genistein liposomes slow release anti-inflammatory |
| FundProject:国家自然科学基金（32172208）；中央财政地方科技发展引导基金（2020JH6/10500002） |
| Author Name | Affiliation | | YAN Huijia1,2, LI Yanfei1,2, LI Sihui1,2, HU Jiangning1,2 | 1.School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, China
2.National Engineering Research Center of Seafood, Dalian 116034, Liaoning, China |
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| Abstract: |
| To improve the bioavailability of genistein (Gen)as well as to provide a reference for the development of lipid-soluble bioactive substances in novel functional foods, nanoliposomes loaded with Gen (Gen@Lip) were prepared by film dispersion method using soy lecithin and cholesterol as raw materials, and their basic indexes, structure, storage stability, in vitro release characteristics and anti-inflammatory activity were investigated. The results showed that the Gen loading, average particle size, polydispersity index, and Zeta potential of the prepared Gen@Lip was 36%, (242.73±2.03) nm, 0.32 and (-16.33±1.16) mV, respectively. The structural characterization results confirmed that Gen was effectively embedded in Gen@Lip, and Gen@Lip had good storage stability. Gen@Lip was able to efficiently pass through the stomach to enter into the intestines to achieve a slow release effect. Compared with free Gen, Gen@Lip had a stronger anti-inflammatory effect on the Raw 264.7 cells and had no toxic side effects within the range of use (＜100 μmol/L). In conclusion, the Gen@Lip prepared can improve the bioavailability of Gen and has significant anti-inflammatory effects. |
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