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| Effect of sunite sheep tail fat on functional metabolism in spontaneously hypertensive rats |
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| DOI： |
| KeyWord:sunite sheep tail fat spontaneously hypertensive rats blood pressure blood lipid liver function |
| FundProject:内蒙古自治区自然科学基金项目（2023MS03034）；内蒙古自治区科技计划项目（2023YFDZ0050）；内蒙古自治区科技计划项目（2021GG0348）；草原英才项目（内组通字\[2021\]333号，内人才发〔2023〕3号） |
| Author Name | Affiliation | | BAO YIN DU GU RONG ·Jinhua1,2,3，CHI Yuan1,2，WU Yanyan1,2，
LI Yawen1,2，HUGE Jiletu3，HOU Ronglun3，ZHOU Huanmin2 | 1.College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010010, China
2.Inner Mongolia Key Laboratory of Biofabrication, Hohhot 010010, China
3.Inner Mongolia Hesige
Agriculture and Animal Husbandry Co. ,Ltd. , Xilin Gol League 026321, Inner Mongolia, China |
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| Abstract: |
| To provide basic data for investigating the effects of sheep tail fat on animal health, a spontaneously hypertensive rat (SHR) model was developed. SHRs with eight weeks of age were allocated into four groups: the experimental group with sunite sheep tail fat (Y group), a negative control group with soybean oil (D group), and two positive control groups with rapeseed oil (C group) and mustard oil (J group), respectively. These groups were provided with diets incorporating 10% of the respective oils. Feed intake was monitored daily, and blood pressure was measured weekly. After a 14-week feeding period, the SHRs were euthanized for collection of blood and liver to assess serum lipid profiles, liver function markers and pathological features. The results showed that the daily feed intake of female and male SHRs at week 14 in the Y groups was significantly higher than that of the control group (p<0.05), while the blood pressure was lower than that of the control group (p<0.05). The total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, along with markers of liver function such as ALT, AST, γ-glutamyl transferase and lactate dehydrogenase were significantly reduced in the Y group compared with control groups (p<0.05). Conversely, high-density lipoprotein cholesterol levels were significantly elevated (p<0.05). Notably, liver tissues from the Y group did not show pathological alterations, in contrast to the significant hepatic lesions observed in the C and J groups. In conclusion, sunite sheep tail fat demonstrates a capacity to moderate blood pressure elevation and enhance blood lipid and liver functions in SHRs, positioning it as an animal fat with potential health benefits. |
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