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| Association between branched/odd-chain fatty acids and intestinal health |
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| DOI： |
| KeyWord:branched-chain fatty acids odd-chain fatty acids intestinal health |
| FundProject:国家自然科学基金面上项目（81972820） |
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| Abstract: |
| To ascertain the effects of branched-chain fatty acids (BCFA) and odd-chain fatty acids (OCFA) on intestinal health, serum fatty acid contents in healthy population and patients with intestinal diseases were measured by gas chromatography-mass spectrometry. Orthogonal partial least-squares discrimination analysis（OPLS-DA）was used to identify characteristic fatty acid of intestinal healthy population. The results showed that 9 kinds of BCFA and 4 kinds of OCFA were detected in the healthy control group, intestinal polyp group and colorectal cancer group. The contents of BCFA and OCFA were significantly higher in healthy population(p<0.05), and the contents of anteiso-C17∶ 0 and C17∶ 0 showed a gradient decreasing trend with the deterioration of intestinal health status (p<0.05). OPLS-DA identified six characteristic fatty acid markers of anteiso-C17∶ 0, iso-C17∶ 0, C18∶ 1, C18∶ 0, C16∶ 0 and C14∶ 0. To sum up, BCFA and OCFA have a potential protective effect on intestinal health. |
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