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| 支链、奇数链脂肪酸与肠道健康的关联性研究 |
| Association between branched/odd-chain fatty acids and intestinal health |
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| DOI： |
| 中文关键词: 支链脂肪酸 奇数链脂肪酸 肠道健康 |
| 英文关键词:branched-chain fatty acids odd-chain fatty acids intestinal health |
| 基金项目:国家自然科学基金面上项目（81972820） |
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| 中文摘要: |
| 为明确支链脂肪酸（BCFA）与奇数链脂肪酸（OCFA）对肠道健康的影响，利用气相色谱-质谱联用分析健康人群与肠道疾病患者血液中脂肪酸含量的差异，并应用正交偏最小二乘-判别分析（OPLS-DA）鉴定肠道健康人群的特征脂肪酸。结果表明：健康对照组、肠道息肉组、结直肠癌组3组人群中共检测出9种BCFA和4种OCFA；BCFA、OCFA含量在健康人群中显著偏高（p<005），其中anteiso-C17∶ 0、C17∶ 0含量随肠道健康状态恶化呈梯度下降趋势（p<0.05）；OPLS-DA共鉴定出anteiso-C17∶ 0、iso-C17∶ 0、C18∶ 1、C18∶ 0、C16∶ 0、C14∶ 0 6种特征脂肪酸标志物。综上，BCFA和OCFA对肠道健康有潜在的保护作用。 |
| 英文摘要: |
| To ascertain the effects of branched-chain fatty acids (BCFA) and odd-chain fatty acids (OCFA) on intestinal health, serum fatty acid contents in healthy population and patients with intestinal diseases were measured by gas chromatography-mass spectrometry. Orthogonal partial least-squares discrimination analysis（OPLS-DA）was used to identify characteristic fatty acid of intestinal healthy population. The results showed that 9 kinds of BCFA and 4 kinds of OCFA were detected in the healthy control group, intestinal polyp group and colorectal cancer group. The contents of BCFA and OCFA were significantly higher in healthy population(p<0.05), and the contents of anteiso-C17∶ 0 and C17∶ 0 showed a gradient decreasing trend with the deterioration of intestinal health status (p<0.05). OPLS-DA identified six characteristic fatty acid markers of anteiso-C17∶ 0, iso-C17∶ 0, C18∶ 1, C18∶ 0, C16∶ 0 and C14∶ 0. To sum up, BCFA and OCFA have a potential protective effect on intestinal health. |
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