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| Evaluation of 90-day subchronic oral toxicity of Cinnamomum camphora seed kernel oil |
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| DOI： |
| KeyWord:Cinnamomum camphora seed kernel oil toxicology 90-day subchronic oral toxicity edible safety |
| FundProject:国家国际科技合作专项项目（2011DFA32770）；国家自然科学基金项目（31701651）；国家自然科学基金项目（32060516）；江西省科技支撑计划重大项目（20143ACG70015）；南昌大学食品与技术国家重点实验室自由探索课题（SKLF-ZZB-202135）；南昌大学食品与技术国家重点实验室自由探索课题（SKLF-ZZB-201916）；江西省重点研发计划项目（20212BBF63035）；江西省科学院省级包干制项目（2022YSBG21021）；江西省科学院省级科研院基础研究项目（2022YJC2016） |
| Author Name | Affiliation | | PENG Ting1,2,3, LIANG Lijun4, ZENG Zheling1,2,5, LI Meina1,2,6, YAN Xianghui1,2,6,
XIA Jiaheng1,2,5, YU Ping1,2,5, WAN Dongman1,2,3, WEN Xuefang7,8 | (1.State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China
2.Jiangxi Province Key Laboratory of Edible and Medicinal Resources Exploitation, Nanchang University,
Nanchang 330031, China
3.School of Food Science and Technology, Nanchang University, Nanchang
330031, China
4.PureCircle（Jiangxi）Co. ,Ltd. ,Ganzhou 341108， Jiangxi, China
5.School of Chemistry
and Chemical Engineering, Nanchang University, Nanchang 330031, China； 6.School of Resources and
Environment, Nanchang University, Nanchang
330031, China； 7.Institute of Applied
Chemistry, Jiangxi Academy of Sciences,
Nanchang 330096, China； 8.Institute of
Traditional Chinese Medicine Health
Industry, China Academy of Chinese
Medical Sciences, Nanchang
330115, China) |
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| Abstract: |
| In order to evaluate the edible safety of Cinnamomum camphora seed kernel oil (CCSKO), four groups of specific pathogen-free (SPF) Sprague-Dawley (SD) rats (20 rats/group, half male and half female) were given CCSKO at doses of 4.0, 2.0, 1.0 mL/kg and 0.0 mL/kg for 90 d by gavage. The subchronic oral toxicity of CCSKO was studied, and its dose-response relationship, toxic target organs and reversibility were explored. The results showed that during the 90-day oral toxicity test, the activity and growth of the rats were normal. There were no significant differences in body weight, weight gain, food intake, food utilization rate, visceral-body ratio, blood routine, blood biochemistry, blood electrolytes and urine between the dose groups and control group(p>0.05), except that the blood glucose of the female and male rats in the high dose group was significantly lower than that in the control group (p<0.05). No significant pathological changes were found in the target organs of CCSKO. In conclusion, CCSKO has no dose-response relationship on the growth and physiology of rats, has no toxic effect on the target organs of rats, and has no dose-response relationship. CCSKO has no subchronic oral toxicity, and its no observed adverse effect level（NOAEL）is higher than 4.0 mL/kg, and it has high safety for consumption. |
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