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| 樟树籽仁油的遗传毒性评价 |
| Genotoxicity evaluation of Cinnamomum camphora seed kernel oil |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.230201 |
| 中文关键词: 樟树籽仁油 食用安全性 遗传毒性 |
| 英文关键词:Cinnamomum camphora seed kernel oil edible safety genotoxicity |
| 基金项目:国家国际科技合作专项项目（2011DFA32770）；国家自然科学基金项目（31701651，32060516）；江西省科技支撑计划重大项目（20143ACG70015）；南昌大学食品与技术国家重点实验室自由探索课题（SKLF-ZZB-202135， SKLF-ZZB-201916）；江西省重点研发计划项目（20212BBF63035）；江西省科学院省级包干制项目（2022YSBG21021）；江西省科学院省级科研院基础研究项目（2022YJC2016） |
| Author Name | Affiliation | | PENG Ting1,2,3, LIANG Lijun4, ZENG Zheling1,2,5, ZHANG Shuhong1,5,
YAN Xianghui1,2,6, XIA Jiaheng1,2,5, YU Ping1,2,5,
WAN Dongman1,2,3, WEN Xuefang7,8 | (1.State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China
2.Jiangxi Province Key Laboratory of Edible and Medicinal Resources Exploitation, Nanchang 330031, China
3.School of Food Science and Technology, Nanchang University, Nanchang 330031, China
4.Pure Circle
（Jiangxi）Co. ,Ltd. ， Ganzhou 341108, Jiangxi, China
5.School of Chemistry and Chemical Engineering,
Nanchang University, Nanchang 330031, China； 6.School of Resources and Environment, Nanchang
University, Nanchang 330031, China；7.Institute of Applied Chemistry, Jiangxi Academy of Sciences,
Nanchang 330096, China
8.Institute of Traditional
Chinese Medicine Health Industry, China Academy of
Chinese Medical Sciences, Nanchang 330115, China) |
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| 中文摘要: |
| 为评价樟树籽仁油的食用安全性，通过细菌回复突变试验、体外哺乳类细胞TK基因突变试验及哺乳动物红细胞微核试验探究樟树籽仁油的致突变和潜在致癌作用。结果表明：樟树籽仁油对组氨酸缺陷型鼠伤寒沙门氏菌TA1535、TA97、TA98、TA100、TA102均无致突变作用；樟树籽仁油未抑制L5178Y小鼠淋巴瘤细胞的生长，对体外哺乳类细胞TK基因无致突变作用；樟树籽仁油未导致小鼠细胞微核率上升，对哺乳动物红细胞无致突变作用，无遗传毒性。综上，樟树籽仁油无细胞致突变和潜在致癌作用，没有遗传毒性，具有一定的食用安全性。 |
| 英文摘要: |
| To evaluate the edible safety of Cinnamomum camphora seed kernel oil (CCSKO), the mutagenicity and potential carcinogenic effects of CCSKO were investigated by bacterial reverse mutation tests, in vitro mammalian cell TK gene mutation tests, and mammalian erythrocyte micronucleus tests. The results showed that CCSKO had no mutagenic effect on Salmonella typhimurium strains TA1535, TA97, TA98, TA100 and TA102 with histidine deficiency. CCSKO did not inhibit the growth of L5178Y mouse lymphoma cells, and had no mutagenic effect on TK gene in mammalian cells in vitro. CCSKO did not increase the micronucleus rate of cell in mice, had no mutagenic effect on mammalian erythrocytes and had no genotoxicity. To sum up, CCSKO has no mutagenicity and potential carcinogenic effect, no genotoxicity, and has certain edible safety. |
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