| In order to improve the utilization of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), the structure, composition, production technology and quality evaluation of SLN and NLC were reviewed. SLN and NLC are carriers of liposoluble substances with solid lipids or mixed lipids as the structural core and with surfactant-stabilized oil-in-water structure. SLN and NLC are composed with oils, emulsifiers and other components. SLN and NLC can be prepared by high energy preparation processes (high pressure homogenization, microjet and ultrasonic) and low energy preparation processes (variable temperature phase transition, microemulsion, film contact and constant temperature reverse transformation). The quality characteristics were evaluated by particle size, Zeta potential, loading capacity, encapsulation rate and crystallization behavior of lipid matrix. Based on the advantages of low toxicity, low biodegradability, high biocompatibility and large-scale production of SLN and NLC, they have become a research hotspot to protect active substances in food or medicine as delivery carriers. |
