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| Evaluation of acute and 42-day high-dose oral toxicity of Cinnamomum camphora seed kernel oil |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.230200 |
| KeyWord:Cinnamomum camphora seed kernel oil edible safety acute oral toxicity subchronic oral toxicity |
| FundProject:国家国际科技合作专项项目（2011DFA32770）；国家自然科学基金项目（31701651）；国家自然科学基金项目（32060516）；江西省科技支撑计划重大项目（20143ACG70015）；南昌大学食品与技术国家重点实验室自由探索课题（SKLF-ZZB-202135，SKLF-ZZB-201916）；江西省重点研发计划项目（20212BBF63035）；江西省科学院省级包干制项目（2022YSBG21021）；江西省科学院省级科研院基础研究项目（2022YJC2016） |
| Author Name | Affiliation | | PENG Ting1,2,3, LIANG Lijun4, ZENG Zheling1,2,5, LUO Miao1,2,3,
YAN Xianghui1,2,6, XIA Jiaheng1,2,5, YU Ping1,2,5,
WAN Dongman1,2,3, WEN Xuefang7,8 | (1.State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China
2.Jiangxi Province Key Laboratory of Edible and Medicinal Resources Exploitation, Nanchang 330031, China
3.School of Food Science and Technology, Nanchang University, Nanchang 330031, China
4.Pure Circle（Jiangxi）Co. , Ltd. ，Ganzhou 341108, Jiangxi, China
5.School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China； 6.School of Resources and Environment, Nanchang University, Nanchang 330031, China；7.Institute of Applied Chemistry, Jiangxi Academy of Sciences, Nanchang 330096, China；8.Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang 330115, China) |
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| Abstract: |
| In order to evaluate the edible safety of Cinnamomum camphora seed kernel oil (CCSKO), the acute toxicity dose and classification of CCSKO were determined by acute oral toxicity test with ICR mice as the test animals, and the subchronic oral toxicity of CCSKO was evaluated by 42-day high-dose（4.0 mL/kg） oral toxicity test with SD rats as the test animals. The results showed that the physiology and activity of ICR mice were normal, no poisoning and death phenomenon, no visible lesions in tissues and organs, and no dose-response relationship. The LD50 of acute oral toxicity of CCSKO to ICR mice was greater than 21.5 g/kg. According to the acute toxicity dose grading standard, CCSKO had no acute oral toxicity and was actually non-toxic. The CCSKO had no effect on the growth and physiology of SD rats, and had no toxic effect on the target organs of SD rats, indicating that CCSKO did not show subchronic oral toxicity during the continuous 42 d feeding period. In conclusion, CCSKO does not have acute oral toxicity or 42-day high-dose oral toxicity, and it has high safety for consumption. |
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