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| Research progress of influences on ω3 and ω6 polyunsaturated fatty acids and their intake ratio on colonic mucosal barrier function |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.230656 |
| KeyWord:ω6 PUFA ω3 PUFA proportion of fatty acid intestinal mucosal barrier |
| FundProject:国家自然科学基金青年基金项目（32201936）；江苏省自然科学基金青年基金项目（BK20221076） |
| Author Name | Affiliation | | DU Shumeng1, LI Rui1, YANG Wei1,2, LIU Yuanfa1,2, YE Zhan1,2 | （1.School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
2.State Key Laboratory of Food Science and Resources, Wuxi 214122, Jiangsu, China） |
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| Abstract: |
| Aiming to provide guidance for a balanced intake of ω3 and ω6 polyunsaturated fatty acids (PUFA) in the population to achieve the prevention of chronic metabolic diseases based on the maintenance of intestinal barrier function, the structure of the mucosal barrier of colonic tissues was outlined, the roles of ω6 and ω3 PUFA intake on its function were summarised, and research progress on the influences of the ratio of ω6 PUFA to ω3 PUFA intake on the colonic mucosal barrier function were reviewed. ω3 PUFA can increase the abundance of beneficial intestinal flora and inhibit the production of pro-inflammatory cytokines, thus regulating the intestinal barrier function; whereas the intake of ω6 PUFA will change the species and number of gut microorganisms in the organism, thus affecting the performance of the intestinal mucosal barrier function. The ratio of ω6 PUFA to ω3 PUFA is closely related to the stability of the colonic mucosal barrier, and a low ratio of ω6 PUFA to ω3 PUFA in fat tissue is significant in reducing the risk of chronic diseases. In the future, further in-depth studies are needed to investigate the mechanism of action of ω6 and ω3 PUFA intake in affecting the colonic mucosal barrier function, so as to provide more precise theoretical references for the dietary guidance of balanced fatty acid intake and the prevention of chronic metabolic diseases. |
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