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| Anti-aging effect and mechanisms of perilla seed oil |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.240161 |
| KeyWord:perilla seed oil mice aging antioxidant |
| FundProject:陕西省重点研发计划项目（2021ZDLSF03-05）；西安医学院校级科技创新团队（2021TD03）；陕西省教育厅科研计划项目（23JP155）；国家级大学生创新创业训练计划项目（202311840020，121522107，121523020）；西安医学院科研能力提升计划项目（2022NLTS070） |
| Author Name | Affiliation | | WANG Rong1,2,3，WANG Nana1,2,3， YANG Kuan1,2,3， LIU Ziqun1，QIN Bei1,2,3 | (1.Xi′an Innovative Antihypertensive Drugs International Science and Technology Cooperation Base
Drugs， Xi′an Key Laboratory for Research and Development of Innovative Multi-Target
Antihypertensive, Xi′an Medical University，Xi′an 710021, China
2.Institute of Drug
Research, Xi′an Medical University, Xi′an 710021, China
3.College of Pharmacy,
Xi′an Medical University, Xi′an 710021, China) |
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| Abstract: |
| Aiming to provide a theoretical basis for the development and utilization of perilla seed oil, the aged mice model was established by injecting D-galactose(500 mg/kg) for continuous 4 weeks at neck back. Mice were randomly divided into model control group, positive control group (VC 200 mg/kg), and perilla seed oil high (5 mL/kg), medium (2.5 mL/kg) and low (1.25 mL/kg) dose groups. After continuous administration for 4 weeks, the body weight and behavioral changes in mice were observed. The motor coordination ability of mice was evaluated by rotarod test and metal mesh method. The organ indexes of brain, thymus and spleen were calculated. The GSH-Px activity and MDA content in serum and brain tissue were evaluated. The pathological morphology in brain tissue were observed by HE staining. The results showed that compared with model control group, the high and medium dose perilla seed oil significantly prolonged the time in rod spinning and on the mesh (p<005), respectively, indicating motor coordination ability of mice was enhanced. The brain index significantly increased in all dose groups of perilla seed oil, and the spleen index also significantly increased in the low dose group. The activity of GSH-Px in serum was significantly improved in the medium and high dose perilla seed oil groups(p<005). The content of MDA in brain were significantly reduced in the medium dose perilla seed oil group (p<0.05). HE staining revealed that the cells in brain tissue of perilla seed oil groups tended to be arranged in an orderly manner, and the cellular structures were intact. In conclusion, perilla seed oil can inhibit the oxidative stress injury and play an anti-aging role in mice. |
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