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| Optimization of preparation process of lutein-DHA composite microcapsules and their storage stability and release properties |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.240586 |
| KeyWord:microcapsules lutein DHA complex coacervation |
| FundProject:国家自然科学基金面上项目（32272325)；国家级大学生创新创业训练计划项目（202310057200) |
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| Abstract: |
| In order to improve the bioavailability of lutein and DHA in human body, lutein-DHA composite microcapsules were prepared by complex coacervation method with lutein and DHA as the core material, and chitosan and carboxymethylcellulose as the wall material, and the process of lutein-DHA composite microcapsules was optimized by single factor and orthogonal experiments and the storage stability and in vitro release properties were investigated. The results showed that the optimal preparation process for lutein-DHA composite microcapsules was pH 3.8, wall material mass concentration 1.0 g/100 mL (mass ratio of chitosan to carboxymethylcellulose 1∶ 1), mono-diglycerides dosage 0.7%(according to mass of DHA algal oil), and core-to-wall ratio 1∶ 2. Under these conditions, the embedding rate of DHA was 84.83%, the embedding rate of lutein was 82.71%, and the microcapsule yield was 8726%. Lutein-DHA composite microcapsules exhibited high thermal stability and low photolysis rates compared to free lutein. In the in vitro simulated release experiments, the relative cumulative release rate of lutein-DHA composite microcapsules was 23.70% for lutein and 20.45% for DHA after 2 h of digestion in simulated gastric fluid, whereas the relative cumulative release rate of lutein was 77.78% for lutein and 84.09% for DHA after 4 h of digestion in simulated intestinal fluid. In conclusion, lutein-DHA composite microcapsules can improve the storage stability and slow release properties of lutein and DHA. |
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