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| Impact of different concentrations of diacylglycerol edible oil on metabolic regulation and liver function in obese mice |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.240270 |
| KeyWord:diacylglycerol lipid metabolism inhibition of body weight gain reduction in blood glucose level liver function |
| FundProject: |
| Author Name | Affiliation | | CHENG Fangyuan1, YANG Xinyue1, LIU Xiaopeng2, WANG Xiuhua1,
LI Wenjuan1, HAN Na1, SONG Qiuyue1 | 1.Changshouhua Food Company Limited, Binzhou 256209，Shandong, China；
2. Binzhou Inspection and Testing Center, Binzhou 256600, Shandong, China |
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| Abstract: |
| To provide a reference for the optimized application of diacylglycerol (DAG) in health management and disease prevention, an obese mice model was established by feeding male C57BL/6J SPF grade mice with a high-fat and high-sugar diet. The obese model group mice were randomly divided into three groups and fed for 16 weeks with high-fat and high-sugar diet where lard was replaced by corn oil, 40% DAG-enriched corn oil, and 80% DAG-enriched corn oil, respectively. The effects of DAG edible oils on body weight, blood lipids, and liver function in obese mice were investigated. The results demonstrated that different concentrations of DAG edible oils effectively inhibited body weight gain, reduced white adipose tissue accumulation, lowered serum levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, and increased high-density lipoprotein cholesterol levels. Additionally, DAG edible oils alleviated hepatic steatosis, mitigated liver damage, and decreased serum glucose content in mice. Notably, 40% DAG-enriched edible oil exhibited superior effects compared to 80% DAG-enriched edible oil. In conclusion, DAG-enriched edible oils can significantly improve lipid metabolism and liver function in obese mice, and in the long-term intervention strategy, 40% DAG-enriched oil may be a better choice. |
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