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| Preparation of distearoyl phosphatidylcholine by semi-synthesis method |
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Received:June 08, 2025 Revised:March 17, 2026 Accepted:August 14, 2025
Published：
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| DOI：10.19902/j.cnki.zgyz.1003-7969.250279 |
| KeyWord:semi-synthesis method egg yolk powder synthetic phospholipids glycerophosphocholine distearoyl phosphatidylcholine |
| FundProject:广东省药用脂质重点实验室（2023B1212070030） |
| Author Name | Affiliation | | TANG Shunzhi1,2,3，LUO Zhengshan1,2,3，ZHAO Zhennan1,2,3，WEN Shuqi1,2,3，
MU Xiaonan1,2,3，SHAO Junfeng4，XU Wendong1,2,3 | 1.Guangzhou Baiyunshan Hanfang Mordern Pharmaceutical Co. , Ltd. , Guangzhou 510240, China
2.National
Engineering Research Center for Pharmaceutical Process Technology and New Drug Development of Traditional
Chinese Medicine, Guangzhou 510240, China
3.Guangdong Provincial Key Laboratory of Medicinal
Lipids, Guangzhou 510240, China
4.Pharmaceutics College, Guangdong Pharmaceutical
University, Guangzhou 510006, China |
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| Abstract: |
| In order to explore the feasibility of preparing distearoyl phosphatidylcholine (DSPC) by semi-synthesis method, glycerophosphocholine (GPC) was obtained from the phospholipid mixture extracted from egg yolk powder by alcoholysis, and then DSPC was obtained by esterification, column separation and other refining processes from GPC. The reaction conditions of alcoholysis and esterification were also optimized. The results showed that the optimal alcoholysis reaction conditions were 5% of the sodium ethoxide dosage (relative to the mass of phospholipid mixture), and the reaction time of 80 min. The optimal esterification reaction conditions were as follows: dicyclohexylcarbodiimide used as the condensing agent, 4-dimethylaminopyridine used as the catalyst, reaction temperature 55 ℃, and reaction time 8 h. Under these conditions, the yield of DSPC was 86.70%, and the content of DSPC was 99.85%. In conclusion, the semi-synthesis method can be used to prepare DSPC. |
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